Literature summary for 2.4.3.4 extracted from

Chandrasekaran, E.V.; Xue, J.; Xia, J.; Locke, R.D.; Matta, K.L.; Neelamegham, S.
Reversible sialylation synthesis of cytidine 5-monophospho-N-acetylneuraminic acid from cytidine 5-monophosphate with alpha2,3-sialyl O-glycan-, glycolipid-, and macromolecule-based donors yields diverse sialylated products (2008), Biochemistry, 47, 320-330 .

Search for more literature for 2.4.3.4

Application

Application	Comment	Organism
synthesis	the enzyme can be exploited for the enzymatic synthesis of diverse sialyl products	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
Sodium citrate	direct sialylation using CMP-N-acetyl-beta-neuraminate	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	Q11205	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CMP + 3-O-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-tyrosyl-[protein]	the enzyme synthesizes CMP-NeuAc by transferring NeuAc from the alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc-unit of O-glycans	Rattus norvegicus	CMP-N-acetyl-beta-neuraminate + 3-O-[beta-D-Gal-(1->3)-alpha-D-GalNAc]-L-tyrosyl-[protein]	-	r

Synonyms

Synonyms	Comment	Organism
ST3Gal-II	-	Rattus norvegicus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
4.8	6.4	formation of CMP-N-acetyl-beta-neuraminate from CMP	Rattus norvegicus
5.2	7.2	direct sialylation using CMP-N-acetyl-beta-neuraminate	Rattus norvegicus

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Release 2023.1 (January 2023)