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Literature summary for 2.4.2.8 extracted from
- Hypoxanthine, guanine, xanthine phosphoribosyltransferase activity in Cryptosporidium parvum (1998), Exp. Parasitol., 89, 9-15.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| adenine | no inhibition | Cryptosporidium parvum |  |
| guanine | competitive | Cryptosporidium parvum | |
| hypoxanthine | competitive | Cryptosporidium parvum | |
| xanthine | weak, competitive | Cryptosporidium parvum | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Cryptosporidium parvum | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| guanine + 5-phospho-alpha-D-ribose 1-diphosphate | Cryptosporidium parvum | - |
GMP + diphosphate | - |
? | |
| hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate | Cryptosporidium parvum | - |
IMP + diphosphate | - |
? | |
| additional information | Cryptosporidium parvum | no incorporation of xanthine in vivo | ? | - |
? | |
| additional information | Cryptosporidium parvum | salvage incorporation of exogenous purine nucleotides, no de novo synthesis | ? | - |
? | |
| additional information | Cryptosporidium parvum | enzyme is essential for salvaging exogenous purine bases | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cryptosporidium parvum | - |
in MDCK cells | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| sporulated oocyst | - |
Cryptosporidium parvum | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.108 | - |
substrate xanthine | Cryptosporidium parvum |
| 0.28 | - |
substrate hypoxanthine | Cryptosporidium parvum |
| 0.346 | - |
substrate guanine | Cryptosporidium parvum |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| guanine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Cryptosporidium parvum | GMP + diphosphate | - |
? | |
| hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Cryptosporidium parvum | IMP + diphosphate | - |
? | |
| additional information | no incorporation of xanthine in vivo | Cryptosporidium parvum | ? | - |
? | |
| additional information | salvage incorporation of exogenous purine nucleotides, no de novo synthesis | Cryptosporidium parvum | ? | - |
? | |
| additional information | enzyme is essential for salvaging exogenous purine bases | Cryptosporidium parvum | ? | - |
? | |
| xanthine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Cryptosporidium parvum | XMP + diphosphate | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Cryptosporidium parvum |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.8 | - |
assay at | Cryptosporidium parvum |
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Release 2023.1 (January 2023)
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