Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.2.47 extracted from

  • Zhang, J.; Angala, S.K.; Pramanik, P.K.; Li, K.; Crick, D.C.; Liav, A.; Jozwiak, A.; Swiezewska, E.; Jackson, M.; Chatterjee, D.
    Reconstitution of functional mycobacterial arabinosyltransferase AftC proteoliposome and assessment of decaprenylphosphorylarabinose analogues as arabinofuranosyl donors (2011), ACS Chem. Biol., 6, 819-828.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.2.47

Activating Compound

Activating Compound Comment Organism Structure
additional information AftC is active only when reconstituted in a proteoliposome Mycobacterium tuberculosis

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Mycobacterium smegmatis mc2155/pJAM/Rv2673 cells Mycobacterium tuberculosis

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mycobacterium tuberculosis 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
38000
-
 x * 38000, SDS-PAGE Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis H37Rv
-
-
-

Purification (Commentary)

Purification (Comment) Organism
metal affinity column column chromatography Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2Z,6Z)-farnesylphospho-alpha-D-arabinofuranoside + octyl (alpha-D-Araf)2-(1->3,5)-alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf
-
 Mycobacterium tuberculosis ?
-
 ?
(2Z,6Z)-farnesylphospho-alpha-D-arabinofuranoside + octyl (alpha-D-Araf)2-(1->3,5)-alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf
-
 Mycobacterium tuberculosis H37Rv ?
-
 ?
(2Z,6Z)-farnesylphospho-alpha-D-arabinofuranoside + octyl alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf
-
 Mycobacterium tuberculosis ?
-
 ?
(2Z,6Z)-farnesylphospho-alpha-D-arabinofuranoside + octyl alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf
-
 Mycobacterium tuberculosis H37Rv ?
-
 ?
decaprenylphospho-alpha-D-arabinofuranoside + octyl alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf
-
 Mycobacterium tuberculosis ?
-
 ?
decaprenylphospho-alpha-D-arabinofuranoside + octyl alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf
-
 Mycobacterium tuberculosis H37Rv ?
-
 ?
ditrans,tetracis-heptaprenylphospho-alpha-D-arabinofuranoside + octyl alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf-(1->5)-alpha-D-Araf
-
 Mycobacterium tuberculosis ?
-
 ?
additional information no activity with octyl alpha-D-Araf-(1->5)-alpha-D-Araf and dipalmitoyl phosphatidylcholine Mycobacterium tuberculosis ?
-
 ?
additional information the enzyme introduces alpha-(1->3) branch points in the internal arabinan domain in both arabinogalactan and lipoarabinomannan synthesis. The enzyme can only transfer D-arabinofuranose when a minimum of three arabinofuranosyl residues are present in a linear structure in order to introduce an alpha-D-Araf-(1->3) branch point Mycobacterium tuberculosis ?
-
 ?
additional information no activity with octyl alpha-D-Araf-(1->5)-alpha-D-Araf and dipalmitoyl phosphatidylcholine Mycobacterium tuberculosis H37Rv ?
-
 ?
additional information the enzyme introduces alpha-(1->3) branch points in the internal arabinan domain in both arabinogalactan and lipoarabinomannan synthesis. The enzyme can only transfer D-arabinofuranose when a minimum of three arabinofuranosyl residues are present in a linear structure in order to introduce an alpha-D-Araf-(1->3) branch point Mycobacterium tuberculosis H37Rv ?
-
 ?

Subunits

Subunits Comment Organism
? x * 38000, SDS-PAGE Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
1,3-alpha-arabinosyltransferase
-
 Mycobacterium tuberculosis
AftC
-
 Mycobacterium tuberculosis
Rv2673
-
 Mycobacterium tuberculosis

General Information

General Information Comment Organism
metabolism the enzyme is involved in the synthesis of the internal alpha-(1->3)-branching of the arabinan domain of arabinogalactan Mycobacterium tuberculosis