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Literature summary for 2.4.2.4 extracted from

  • de Bruin, M.; Smid, K.; Laan, A.C.; Noordhuis, P.; Fukushima, M.; Hoekman, K.; Pinedo, H.M.; Peters, G.J.
    Rapid disappearance of deoxyribose-1-phosphate in platelet derived endothelial cell growth factor/thymidine phosphorylase overexpressing cells (2003), Biochem. Biophys. Res. Commun., 301, 675-679.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
transfected into colon cancer cell line Colo320 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information a specific thymidine phosphorylase inhibitor TPI completely inhibits Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens angiogenic activity ?
-
 ?
thymine + 2-deoxy-D-ribose 1-phosphate Homo sapiens
-
 thymidine + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information angiogenic activity Homo sapiens ?
-
 ?
thymidine + phosphate
-
 Homo sapiens thymine + 2-deoxy-D-ribose 1-phosphate
-
 ?
thymine + 2-deoxy-D-ribose 1-phosphate
-
 Homo sapiens thymidine + phosphate
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
10
-
 assay at, pH 10 is used because 2-deoxy-D-ribose 1-phosphate is heat labile at pH 7.4 Homo sapiens