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Literature summary for 2.4.2.30 extracted from

  • Faraone-Mennella, M.R.; Piccialli, G.; De Luca, P.; Castellano, S.; Giordano, A.; Rigano, D.; De Napoli, L.; Farina, B.
    Interaction of the ADP-ribosylating enzyme from the hyperthermophilic archaeon Sulfolobus solfataricus with DNA and ss-oligo deoxy ribonucleotides (2002), J. Cell. Biochem., 85, 146-157.
    View publication on PubMed
Search for more literature for 2.4.2.30

Activating Compound

Activating Compound Comment Organism Structure
DNA slightly increases activity Saccharolobus solfataricus
oligodeoxyribonucleotides slightly enhance enzyme activity with the maximal increase of 50% as compared to the control Saccharolobus solfataricus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + (ADP-D-ribosyl)n-acceptor Saccharolobus solfataricus the emzyme protects homologous DNA against thermal denaturation by lowering the amount of melted DNA and increasing melting temperature. The archaeal protein induces structural changes of the nucleic acid by modifying the dichroic spectra towards a shape typical of condensing DNA nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
-
 ?
NAD+ + (ADP-D-ribosyl)n-acceptor Saccharolobus solfataricus MT-4 / DSM 5833 the emzyme protects homologous DNA against thermal denaturation by lowering the amount of melted DNA and increasing melting temperature. The archaeal protein induces structural changes of the nucleic acid by modifying the dichroic spectra towards a shape typical of condensing DNA nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharolobus solfataricus B3EWG9
-
-
Saccharolobus solfataricus MT-4 / DSM 5833 B3EWG9
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Saccharolobus solfataricus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + (ADP-D-ribosyl)n-acceptor
-
 Saccharolobus solfataricus nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
-
 ?
NAD+ + (ADP-D-ribosyl)n-acceptor the emzyme protects homologous DNA against thermal denaturation by lowering the amount of melted DNA and increasing melting temperature. The archaeal protein induces structural changes of the nucleic acid by modifying the dichroic spectra towards a shape typical of condensing DNA Saccharolobus solfataricus nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
-
 ?
NAD+ + (ADP-D-ribosyl)n-acceptor
-
 Saccharolobus solfataricus MT-4 / DSM 5833 nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
-
 ?
NAD+ + (ADP-D-ribosyl)n-acceptor the emzyme protects homologous DNA against thermal denaturation by lowering the amount of melted DNA and increasing melting temperature. The archaeal protein induces structural changes of the nucleic acid by modifying the dichroic spectra towards a shape typical of condensing DNA Saccharolobus solfataricus MT-4 / DSM 5833 nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
80
-
 assay at Saccharolobus solfataricus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Saccharolobus solfataricus