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Literature summary for 2.4.2.30 extracted from

  • Baumann, C.; Boehden, G.S.; Buerkle, A.; Wiesmueller, L.
    Poly(ADP-RIBOSE) polymerase-1 (Parp-1) antagonizes topoisomerase I-dependent recombination stimulation by P53 (2006), Nucleic Acids Res., 34, 1036-1049.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.2.30

Cloned(Commentary)

Cloned (Comment) Organism
gene parp-1, expression in LMV cells and subclones, derived from the parental line LLC-MK2 from rhesus monkey Macaca mulatta kidney, stably expressing the estradiol-inducible transcriptional transactivation factor Gal4ERVP Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information downregulatory effect of PARP-1 on the p53-dependent regulation of recombination between SV40 minichromosomes in primate cell lines conditionally expressing exogenous PARP-1 in a wild-type p53-positive or -negative background, respectively, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus PARP-1 plays fundamental roles in the recruitment and modulation of enzymatic and regulatory factors involved in transcription, DNA replication, repair and recombination, the enzyme antagonizes topoisomerase I-dependent recombination stimulation by P53 ?
-
 ?
NAD+ + (ADP-D-ribosyl)n-acceptor Mus musculus
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 nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?
NAD+ + p53 Mus musculus
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 nicotinamide + (ADP-D-ribosyl)-p53
-
 ?
NAD+ + topoisomerase I Mus musculus
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 nicotinamide + (ADP-D-ribosyl)-topoisomerase I
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PARP-1 plays fundamental roles in the recruitment and modulation of enzymatic and regulatory factors involved in transcription, DNA replication, repair and recombination, the enzyme antagonizes topoisomerase I-dependent recombination stimulation by P53 Mus musculus ?
-
 ?
NAD+ + (ADP-D-ribosyl)n-acceptor
-
 Mus musculus nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?
NAD+ + p53
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 Mus musculus nicotinamide + (ADP-D-ribosyl)-p53
-
 ?
NAD+ + p53 PARP-1 interacts with and poly(ADP-ribosyl)ates p53, which participates in DNA recombination Mus musculus nicotinamide + (ADP-D-ribosyl)-p53
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 ?
NAD+ + topoisomerase I
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 Mus musculus nicotinamide + (ADP-D-ribosyl)-topoisomerase I
-
 ?
NAD+ + topoisomerase I PARP-1 interacts with and poly(ADP-ribosyl)ates topoisomerase I, which participates in DNA recombination, I-SceI-meganuclease-mediated cleavage terminates the interaction, overview Mus musculus nicotinamide + (ADP-D-ribosyl)-topoisomerase I
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 ?

Synonyms

Synonyms Comment Organism
PARP-1
-
 Mus musculus
poly(ADP-ribose) polymerase-1
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 Mus musculus