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Literature summary for 2.4.2.30 extracted from

  • Zhao, Z.; Gruszczynska-Biegala, J.; Zolkiewska, A.
    ADP-ribosylation of integrin alpha7 modulates the binding of integrin alpha7beta1 to laminin (2005), Biochem. J., 385, 309-317.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.2.30

Protein Variants

Protein Variants Comment Organism
additional information effects of ADP-ribosylation of integrin alpha7 on the expression of the monoclonal anti-integrin antibody 9EG7 epitope in intact differentiated C2C12 cells in presence or absene of NAD+ and Mn2+, overview Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ required for activity, cannot be substituted by Mg2+ Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
integrin alpha7 + NAD+ Mus musculus the extracellular domain of integrin alpha7 is ADP-ribosylated by an arginine-specific ecto-ADP-ribosyltransferase after adding exogenous NAD+ to intact C2C12 muscle cells, integrin alpha7 N-terminal ADP-ribosylation inhibits the binding of integrin alpha7beta1 to laminin activation status of integrin alpha7beta1 in intact myotubes, overview (ADP-D-ribosyl)-integrin alpha7 + nicotinamide
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
C2C12 cell
-
 Mus musculus
-
myoblast
-
 Mus musculus
-
skeletal muscle
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
integrin alpha7 + NAD+ the extracellular domain of integrin alpha7 is ADP-ribosylated by an arginine-specific ecto-ADP-ribosyltransferase after adding exogenous NAD+ to intact C2C12 muscle cells, integrin alpha7 N-terminal ADP-ribosylation inhibits the binding of integrin alpha7beta1 to laminin activation status of integrin alpha7beta1 in intact myotubes, overview Mus musculus (ADP-D-ribosyl)-integrin alpha7 + nicotinamide
-
 ?
integrin alpha7 + NAD+ the extracellular domain of integrin alpha7 is ADP-ribosylated by an arginine-specific ecto-ADP-ribosyltransferase after adding exogenous NAD+ to intact C2C12 muscle cells, integrin alpha7 ADP-ribosylation inhibits the binding of integrin alpha7beta1 to laminin, binding site, overview Mus musculus (ADP-D-ribosyl)-integrin alpha7 + nicotinamide
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus