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Literature summary for 2.4.2.30 extracted from

  • Pagano, A.; Metrailler-Ruchonnet, I.; Aurrand-Lions, M.; Lucattelli, M.; Donati, Y.; Barazzone-Argiroffo, C.
    Poly(ADP-ribose) polymerase-1 (PARP-1) controls lung cell proliferation and repair after hyperoxia-induced lung damage (2007), Am. J. Physiol. Lung Cell Mol. Physiol., 293, L619-L629.
    View publication on PubMed
Search for more literature for 2.4.2.30

Activating Compound

Activating Compound Comment Organism Structure
additional information PARP-1 is activated in response to DNA damage and participates in DNA repair, genomic integrity and cell death Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information knockout mice show increased inflammatory response in PARP-1 -/- compared to wild-type animals, characterized by neutrophil infiltration and increased IL-6 levels in broncho-alveolar lavages, the lesions are reversible, since the extent of the hyperplastic regions is reduced after 21 days of recovery and do not result in fibrosis, phenotype, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
PJ34 potent PARP inhibitor Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus PARP-1 plays an essential role in the control of cell repair and tissue remodeling after hyperoxia-induced lung injury, overview ?
-
 ?
additional information Mus musculus Sv129 PARP-1 plays an essential role in the control of cell repair and tissue remodeling after hyperoxia-induced lung injury, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 Sv129 mice
-
Mus musculus Sv129
-
 Sv129 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell
-
 Mus musculus
-
fibroblast primary, from lung Mus musculus
-
lung PARP-1 in lung repair during recovery after hyperoxia, that is induced by 5-bromo-2’-deoxyuridine, overview Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PARP-1 plays an essential role in the control of cell repair and tissue remodeling after hyperoxia-induced lung injury, overview Mus musculus ?
-
 ?
additional information PARP-1 plays an essential role in the control of cell repair and tissue remodeling after hyperoxia-induced lung injury, overview Mus musculus Sv129 ?
-
 ?

Synonyms

Synonyms Comment Organism
PARP-1
-
 Mus musculus
poly(ADP-ribose) polymerase-1
-
 Mus musculus