Literature summary for 2.4.2.30 extracted from

Ganesan, A.K.; Vincent, T.S.; Olson, J.C.; Barbieri, J.T.
Pseudomonas aeruginosa exoenzyme S disrupts Ras-mediated signal transduction by inhibiting guanine nucleotide exchange factor-catalyzed nucleotide exchange (1999), J. Biol. Chem., 274, 21823-21829.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
NAD+ + (ADP-D-ribosyl)n-Ras	Pseudomonas aeruginosa	ADP-ribosylation of Ras at Arg41 disrupts Ras-Cdc25 interactions, which inhibits the rate-limiting step in Ras signal transduction, the activation of Ras by its guanine nucleotide exchange factor	nicotinamide + (ADP-D-ribosyl)n+1-Ras	-	?

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NAD+ + (ADP-D-ribosyl)n-Ras	-	Pseudomonas aeruginosa	nicotinamide + (ADP-D-ribosyl)n+1-Ras	-	?
NAD+ + (ADP-D-ribosyl)n-Ras	ADP-ribosylation of Ras at Arg41 disrupts Ras-Cdc25 interactions, which inhibits the rate-limiting step in Ras signal transduction, the activation of Ras by its guanine nucleotide exchange factor	Pseudomonas aeruginosa	nicotinamide + (ADP-D-ribosyl)n+1-Ras	-	?

Synonyms

Synonyms	Comment	Organism
exoenzyme S	-	Pseudomonas aeruginosa

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Release 2023.1 (January 2023)