Cloned (Comment) | Organism |
---|---|
- |
Tequatrovirus T4 |
Protein Variants | Comment | Organism |
---|---|---|
E118A | mutation reduces the toxicity of the enzyme and still allows small colonies to grow | Tequatrovirus T4 |
E163A | mutation reduces toxicity of ModA to a minor extent | Tequatrovirus T4 |
E165A | mutation in ModA reduces the toxicity to colony growth | Tequatrovirus T4 |
E171A | mutation reduces the toxicity of the enzyme and still allows small colonies to grow | Tequatrovirus T4 |
E173A | mutation largly abolishes enzyme activity | Tequatrovirus T4 |
F127A | mutation in ModA reduces the toxicity to colony growth | Tequatrovirus T4 |
F129A | mutation in ModA reduces the toxicity to colony growth | Tequatrovirus T4 |
F129A | mutation largly abolishes enzyme activity | Tequatrovirus T4 |
I176A | mutation reduces the toxicity of the enzyme and still allows small colonies to grow | Tequatrovirus T4 |
L71A | mutation largly abolishes enzyme activity | Tequatrovirus T4 |
N128A | mutation reduces toxicity of ModA to a minor extent | Tequatrovirus T4 |
N130A | mutant enzyme with toxicity close to that of wild-type enzyme | Tequatrovirus T4 |
Q116A | mutation reduces toxicity of ModA to a minor extent | Tequatrovirus T4 |
Q164A | mutation reduces toxicity of ModA to a minor extent | Tequatrovirus T4 |
Q172A | mutant enzyme with toxicity close to that of wild-type enzyme | Tequatrovirus T4 |
R72A | mutation in ModA reduces the toxicity to colony growth | Tequatrovirus T4 |
R73A | mutation largly abolishes enzyme activity | Tequatrovirus T4 |
S109A | mutation in ModA reduces the toxicity to colony growth | Tequatrovirus T4 |
S111A | mutant enzyme with toxicity close to that of wild-type enzyme | Tequatrovirus T4 |
Y131A | mutation largly abolishes enzyme activity | Tequatrovirus T4 |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + RNA polymerase | Tequatrovirus T4 | three ADP-ribosyltransferases, Alt, ModA, and ModB participate in the regulation of the T4 replication cycle by ADP-ribosylating a defined set of host proteins. ADP-ribosylation of RNA polymerase and of other host proteins allows initial phage-directed mRNA synthesis reactions to escape from host control | nicotinamide + (ADP-D-ribosyl)-RNA polymerase | - |
? | |
NAD+ + RNA polymerase | Tequatrovirus T4 ModA | three ADP-ribosyltransferases, Alt, ModA, and ModB participate in the regulation of the T4 replication cycle by ADP-ribosylating a defined set of host proteins. ADP-ribosylation of RNA polymerase and of other host proteins allows initial phage-directed mRNA synthesis reactions to escape from host control | nicotinamide + (ADP-D-ribosyl)-RNA polymerase | - |
? | |
NAD+ + RNA polymerase | Tequatrovirus T4 ModB | three ADP-ribosyltransferases, Alt, ModA, and ModB participate in the regulation of the T4 replication cycle by ADP-ribosylating a defined set of host proteins. ADP-ribosylation of RNA polymerase and of other host proteins allows initial phage-directed mRNA synthesis reactions to escape from host control | nicotinamide + (ADP-D-ribosyl)-RNA polymerase | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Tequatrovirus T4 | P12726 | ModA | - |
Tequatrovirus T4 | P12726 | ModB | - |
Tequatrovirus T4 ModA | P12726 | ModA | - |
Tequatrovirus T4 ModB | P12726 | ModB | - |
Purification (Comment) | Organism |
---|---|
- |
Tequatrovirus T4 |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + RNA polymerase | - |
Tequatrovirus T4 | nicotinamide + (ADP-D-ribosyl)-RNA polymerase | - |
? | |
NAD+ + RNA polymerase | three ADP-ribosyltransferases, Alt, ModA, and ModB participate in the regulation of the T4 replication cycle by ADP-ribosylating a defined set of host proteins. ADP-ribosylation of RNA polymerase and of other host proteins allows initial phage-directed mRNA synthesis reactions to escape from host control | Tequatrovirus T4 | nicotinamide + (ADP-D-ribosyl)-RNA polymerase | - |
? | |
NAD+ + RNA polymerase | - |
Tequatrovirus T4 ModA | nicotinamide + (ADP-D-ribosyl)-RNA polymerase | - |
? | |
NAD+ + RNA polymerase | three ADP-ribosyltransferases, Alt, ModA, and ModB participate in the regulation of the T4 replication cycle by ADP-ribosylating a defined set of host proteins. ADP-ribosylation of RNA polymerase and of other host proteins allows initial phage-directed mRNA synthesis reactions to escape from host control | Tequatrovirus T4 ModA | nicotinamide + (ADP-D-ribosyl)-RNA polymerase | - |
? | |
NAD+ + RNA polymerase | - |
Tequatrovirus T4 ModB | nicotinamide + (ADP-D-ribosyl)-RNA polymerase | - |
? | |
NAD+ + RNA polymerase | three ADP-ribosyltransferases, Alt, ModA, and ModB participate in the regulation of the T4 replication cycle by ADP-ribosylating a defined set of host proteins. ADP-ribosylation of RNA polymerase and of other host proteins allows initial phage-directed mRNA synthesis reactions to escape from host control | Tequatrovirus T4 ModB | nicotinamide + (ADP-D-ribosyl)-RNA polymerase | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ModA | - |
Tequatrovirus T4 |
ModB | - |
Tequatrovirus T4 |