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Literature summary for 2.4.2.3 extracted from

  • Johansson, M.
    Identification of a novel human uridine phosphorylase (2003), Biochem. Biophys. Res. Commun., 307, 41-46.
    View publication on PubMed
Search for more literature for 2.4.2.3

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli as a fusion protein to glutathione-S-transferase Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.024
-
 5-fluorouridine pH 7.4, 37°C Homo sapiens
0.073
-
 thymidine pH 7.4, 37°C Homo sapiens
0.076
-
 uridine pH 7.4, 37°C Homo sapiens
0.3
-
 deoxyuridine pH 7.4, 37°C Homo sapiens
0.427
-
 5-fluoro-2'-deoxyuridine pH 7.4, 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O95045
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney Upase-2 is predominantly expressed in Homo sapiens
-
liver Upase-2 is predominantly expressed in Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-fluoro-2'-deoxyuridine + phosphate
-
 Homo sapiens 5-fluorouracil + 2-deoxy-alpha-D-ribose 1-phosphate
-
 ?
5-fluorouridine + phosphate
-
 Homo sapiens 5-fluorouracil + alpha-D-ribose-1-phosphate
-
 ?
deoxyuridine + phosphate
-
 Homo sapiens uracil + 2-deoxy-alpha-D-ribose 1-phosphate
-
 ?
thymidine + phosphate
-
 Homo sapiens thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
 ?
uridine + phosphate
-
 Homo sapiens uracil + alpha-D-ribose 1-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
UPase-2
-
 Mus musculus
UPase-2
-
 Homo sapiens
uridine phosphorylase-2
-
 Mus musculus
uridine phosphorylase-2
-
 Homo sapiens