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Literature summary for 2.4.2.3 extracted from

  • Veres, Z.; Neszmelyi, A.; Szabolcs, A.; Denes, G.
    Inhibition of uridine phosphorylase by pyrimidine nucleoside analogs and consideration of substrate binding to the enzyme based on solution conformation as seen by NMR spectroscopy (1988), Eur. J. Biochem., 178, 173-181.
    View publication on PubMed
Search for more literature for 2.4.2.3

Inhibitors

Inhibitors Comment Organism Structure
2',3'-Dideoxy-5-ethyluridine
-
 Rattus norvegicus
2'-deoxylyxofuranosyl-5-ethyluracil
-
 Rattus norvegicus
2,2'-Anhydro-5-ethyluridine
-
 Rattus norvegicus
2,3'-Anhydro-2'-deoxy-5-ethyluridine
-
 Rattus norvegicus
2,5'-Anhydro-2'-deoxy-5-ethyluridine
-
 Rattus norvegicus
3'-Azido-2',3'-dideoxy-5-ethyluridine
-
 Rattus norvegicus
3'-Azido-2',3'-dideoxy-5-methyluridine
-
 Rattus norvegicus
3'-Bromo-2',3'-dideoxy-5-ethyluridine
-
 Rattus norvegicus
3'-Chloro-2',3'-dideoxy-5-ethyluridine
-
 Rattus norvegicus
3'-Chloro-2',3'-dideoxy-5-methyluridine
-
 Rattus norvegicus
3'-O-Acetyl-2,2'-anhydro-5-ethyluridine
-
 Rattus norvegicus
Arabinofuranosyl-5-ethyluracil
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
intestinal mucosa
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arabinofuranosyl-5-ethyluracil + phosphate weak substrate Rattus norvegicus 5-ethyluracil + arabinose-1-phosphate
-
 ?
additional information no substrates: 3'-azido-2',3'-dideoxy-5-methyluridine, 3'-azido-2',3'-dideoxy-5-ethyluridine, 2',3'-dideoxy-5-ethyluridine, 3'-chloro-2',3'-dideoxy-5-ethyluridine, 3'-chloro-2',3'-dideoxy-5-methyluridine, 3'-bromo-2',3'-dideoxy-5-ethyluridine, 2'-deoxylyxofuranosyl-5-ethyluracil, 3'-O-acetyl-2,2'-anhydro-5-ethyluridine, 2,3'-anhydro-2'-deoxy-5-ethyluridine, 2,5'-anhydro-2'-deoxy-5-ethyluridine Rattus norvegicus ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.056
-
 3'-Azido-2',3'-dideoxy-5-methyluridine
-
 Rattus norvegicus
0.107
-
 Arabinofuranosyl-5-ethyluracil
-
 Rattus norvegicus
0.109
-
 2',3'-Dideoxy-5-ethyluridine
-
 Rattus norvegicus
0.21
-
 3'-Chloro-2',3'-dideoxy-5-ethyluridine
-
 Rattus norvegicus
0.225
-
 3'-Azido-2',3'-dideoxy-5-ethyluridine
-
 Rattus norvegicus
0.361
-
 3'-Chloro-2',3'-dideoxy-5-methyluridine
-
 Rattus norvegicus
0.448
-
 3'-Bromo-2',3'-dideoxy-5-ethyluridine
-
 Rattus norvegicus
1.003
-
 2'-deoxylyxofuranosyl-5-ethyluracil
-
 Rattus norvegicus