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Literature summary for 2.4.2.28 extracted from

  • Guan, R.; Tyler, P.C.; Evans, G.B.; Schramm, V.L.
    Thermodynamic analysis of transition-state features in picomolar inhibitors of human 5'-methylthioadenosine phosphorylase (2013), Biochemistry, 52, 8313-8322.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.2.28

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21-CodonPlus(DE3)-RIPL cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4-Cl-PhT-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin A
-
 Homo sapiens
5-methylthio-4'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin A
-
 Homo sapiens
5-methylthio-immucillin A
-
 Homo sapiens
9-deazaadenine
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-methyl-5'-thioadenosine + phosphate Homo sapiens
-
 adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13126
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-methyl-5'-thioadenosine + phosphate
-
 Homo sapiens adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
-
 ?

Subunits

Subunits Comment Organism
homotrimer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
5'-methylthioadenosine phosphorylase
-
 Homo sapiens
MTAP
-
 Homo sapiens