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Literature summary for 2.4.2.28 extracted from

  • Nobori, T.; Takabayashi, K.; Tran, P.; Orvis, L.; Batova, A.; Yu, A.L.; Carson, D.A.
    Genomic cloning of methylthioadenosine phosphorylase: a purine metabolic enzyme deficient in multiple different cancers (1996), Proc. Natl. Acad. Sci. USA, 93, 6203-6208.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
from cells of patients with T-cell acute lymphoblastic leukemia, DNA sequence analysis, 9p21 chromosome, topologic map Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme plays a role in purine and polyamine metabolism and in the regulation of transmethylation reactions ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13126
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mononuclear cell
-
 Homo sapiens
-
additional information enzyme deficiency in malignant cells, partial or total deletions in the gene of leukemia cell lines of patients with T-cell acute lymphoblastic leukemia Homo sapiens
-
peripheral blood
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-deoxy-5'-methylthioadenosine + phosphate
-
 Homo sapiens adenine + 5-methylthio-D-ribose 1-phosphate
-
 ?
5'-methylthioadenosine + phosphate
-
 Homo sapiens adenine + 5-methylthio-D-ribose 1-phosphate
-
 ?
additional information enzyme plays a role in purine and polyamine metabolism and in the regulation of transmethylation reactions Homo sapiens ?
-
 ?