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Literature summary for 2.4.2.28 extracted from

  • Garbers, D.L.
    Demonstration of 5'-methylthioadenosine phosphorylase activity in various rat tissues. Some properties of the enzyme from rat lung (1978), Biochim. Biophys. Acta, 523, 82-93.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
putrescine no effect Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
2-Deoxyribose 1-phosphate
-
Rattus norvegicus
adenine
-
Rattus norvegicus
fructose 1-phosphate
-
Rattus norvegicus
guanine
-
Rattus norvegicus
L-methionine weak Rattus norvegicus
additional information no inhibition by EDTA, putrescine, cadaverine Rattus norvegicus
ribose 1-phosphate
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information no requirement for metal ion, e.g. Mg2+, Mn2+ or Ca2+ Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
from lung Rattus norvegicus
partial Rattus norvegicus

Reaction

Reaction Comment Organism Reaction ID
S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate phosphorolytic mechanism Rattus norvegicus
S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate equilibrium-ordered reaction, 5'-methylthioadenosine is the first substrate to bind and 5-methylthioribose 1-phosphate is the first product to be released Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
heart low activity Rattus norvegicus
-
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
lung
-
Rattus norvegicus
-
additional information wide tissue distribution Rattus norvegicus
-
spleen
-
Rattus norvegicus
-
testis
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
kinetics Rattus norvegicus

Storage Stability

Storage Stability Organism
-70°C, stable for at least 4 months Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-methylthioadenosine + phosphate
-
Rattus norvegicus adenine + 5-methylthio-D-ribose 1-phosphate
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4 8
-
Rattus norvegicus