Cloned (Comment) | Organism |
---|---|
expressed in the xylosyltransferase-deficient pgsA-745 (S745) CHO cell line and in Pichia pastoris | Homo sapiens |
expression in Pichia pastoris. Soluble form of human XT-II is expressed in the xylosyltransferase-deficient pgsA-745 (S745) Chinese hamster ovary cell line | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.25 | - |
UDP-D-xylose | about | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | active in the absence of any added cation | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | first enzyme required for the generation of chondroitin and heparan sulfate glycosaminoglycan chains of proteoglycans | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q86Y38 | - |
- |
Homo sapiens | Q9H1B5 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | first enzyme required for the generation of chondroitin and heparan sulfate glycosaminoglycan chains of proteoglycans | Homo sapiens | ? | - |
? | |
UDP-D-xylose + bikunin | - |
Homo sapiens | UDP + D-xylosyl-bikunin | - |
? | |
UDP-D-xylose + DDDSIEGSGGR | - |
Homo sapiens | UDP + DDDSIEG(D-xylosyl)SGGR | - |
? | |
UDP-D-xylose + DDDSIEGSGGR | syndecan peptide substrate | Homo sapiens | UDP + DDDSIEG(D-xylosyl)SGGR | - |
? | |
UDP-D-xylose + DSISGDDLGSGDLGSGDFQR | - |
Homo sapiens | ? | - |
? | |
UDP-D-xylose + DSISGDDLGSGDLGSGDFQR | - |
Homo sapiens | UDP + ? | - |
? | |
UDP-D-xylose + QEEEGSGGGGQR | - |
Homo sapiens | UDP + QEEEG(D-xylosyl)SGGGGQR | - |
? |
Synonyms | Comment | Organism |
---|---|---|
peptide O-xylosyltransferase | - |
Homo sapiens |
peptide-O-xylosyltransferase | - |
Homo sapiens |
XT-I | - |
Homo sapiens |
XT-I | isozyme | Homo sapiens |
XT-II | - |
Homo sapiens |
XT-II | isozyme | Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
- |
Homo sapiens |
Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|
15 | 37 | 15°C: about 40% of maximal activity, 37°C: maximal activity | Homo sapiens |
16 | 37 | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | 8 | - |
Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.5 | 9 | pH 6.5: about 60% of maximal activity, pH 9.0: about 60% of maximal activity | Homo sapiens |
6.5 | 8.5 | pH 6.5: about 70% of maximal activity, pH 8.5: about 60% of maximal activity | Homo sapiens |