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Literature summary for 2.4.2.2 extracted from

  • Vande Voorde, J.; Liekens, S.; Gago, F.; Balzarini, J.
    The pyrimidine nucleoside phosphorylase of Mycoplasma hyorhinis and how it may affect nucleoside-based therapy (2014), Nucleosides Nucleotides Nucleic Acids, 33, 394-402.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) pLysS cells Mycoplasma hyorhinis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.095
-
uridine at pH 7.6 and 37°C Mycoplasma hyorhinis
0.365
-
thymidine at pH 7.6 and 37°C Mycoplasma hyorhinis
0.856
-
5-trifluorothymidine at pH 7.6 and 37°C Mycoplasma hyorhinis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mycoplasma hyorhinis the enzyme also displays (2'-deoxy)ribosyltransferase activity ?
-
?
additional information Mycoplasma hyorhinis ATCC 17981 the enzyme also displays (2'-deoxy)ribosyltransferase activity ?
-
?
thymidine + phosphate Mycoplasma hyorhinis
-
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
?
thymidine + phosphate Mycoplasma hyorhinis ATCC 17981
-
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
?
uridine + phosphate Mycoplasma hyorhinis
-
uracil + alpha-D-ribose 1-phosphate
-
?
uridine + phosphate Mycoplasma hyorhinis ATCC 17981
-
uracil + alpha-D-ribose 1-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Mycoplasma hyorhinis
-
-
-
Mycoplasma hyorhinis ATCC 17981
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-trifluorothymidine + phosphate
-
Mycoplasma hyorhinis 5-trifluorothymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
?
5-trifluorothymidine + phosphate
-
Mycoplasma hyorhinis ATCC 17981 5-trifluorothymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
?
additional information the enzyme also displays (2'-deoxy)ribosyltransferase activity Mycoplasma hyorhinis ?
-
?
additional information the enzyme also displays (2'-deoxy)ribosyltransferase activity Mycoplasma hyorhinis ATCC 17981 ?
-
?
thymidine + phosphate
-
Mycoplasma hyorhinis thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
?
thymidine + phosphate
-
Mycoplasma hyorhinis ATCC 17981 thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
?
uridine + phosphate
-
Mycoplasma hyorhinis uracil + alpha-D-ribose 1-phosphate
-
?
uridine + phosphate
-
Mycoplasma hyorhinis ATCC 17981 uracil + alpha-D-ribose 1-phosphate
-
?

Synonyms

Synonyms Comment Organism
PYNP
-
Mycoplasma hyorhinis
pyrimidine nucleoside phosphorylase
-
Mycoplasma hyorhinis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
8.25
-
5-trifluorothymidine at pH 7.6 and 37°C Mycoplasma hyorhinis
9.03
-
uridine at pH 7.6 and 37°C Mycoplasma hyorhinis
20.5
-
thymidine at pH 7.6 and 37°C Mycoplasma hyorhinis

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
10
-
5-trifluorothymidine at pH 7.6 and 37°C Mycoplasma hyorhinis
56.7
-
thymidine at pH 7.6 and 37°C Mycoplasma hyorhinis
95
-
uridine at pH 7.6 and 37°C Mycoplasma hyorhinis