Application | Comment | Organism |
---|---|---|
medicine | the cytostatic and antiviral activity of pyrimidine nucleoside analogues is markedly decreased by a Mycoplasma hyorhinis infection and the phosphorolytic activity of the mycoplasmas is responsible for this | Mycoplasma hyorhinis |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Mycoplasma hyorhinis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-benzylacyclouridine | - |
Mycoplasma hyorhinis | |
5-chloro-6-(1-[2-iminopyrrolidinyl]methyl)uracil | - |
Mycoplasma hyorhinis | |
7-deazaxanthine | - |
Mycoplasma hyorhinis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.047 | - |
5-fluorouridine | pH 7.6, 37°C | Mycoplasma hyorhinis | |
0.069 | - |
5-iodouridine | pH 7.6, 37°C | Mycoplasma hyorhinis | |
0.092 | - |
uridine | pH 7.6, 37°C | Mycoplasma hyorhinis | |
0.144 | - |
5-iododeoxyuridine | pH 7.6, 37°C | Mycoplasma hyorhinis | |
0.169 | - |
5-fluorodeoxyuridine | pH 7.6, 37°C | Mycoplasma hyorhinis | |
0.388 | - |
phosphate | cosubstrate uridine, pH 7.6, 37°C | Mycoplasma hyorhinis | |
0.473 | - |
thymidine | pH 7.6, 37°C | Mycoplasma hyorhinis | |
0.578 | - |
deoxyuridine | pH 7.6, 37°C | Mycoplasma hyorhinis | |
0.797 | - |
phosphate | cosubstrate deoxythymidine, pH 7.6, 37°C | Mycoplasma hyorhinis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycoplasma hyorhinis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-bromodeoxyuridine + phosphate | - |
Mycoplasma hyorhinis | 5-bromouracil + 2-deoxy-D-ribose 1-phosphate | - |
? | |
5-chlorodeoxyuridine + phosphate | - |
Mycoplasma hyorhinis | 5-chlorouracil + 2-deoxy-D-ribose 1-phosphate | - |
? | |
5-fluorodeoxyuridine + phosphate | - |
Mycoplasma hyorhinis | 5-fluorouracil + 2-deoxy-D-ribose 1-phosphate | - |
? | |
5-fluorouridine + phosphate | - |
Mycoplasma hyorhinis | 5-fluorouracil + alpha-D-ribose 1-phosphate | - |
? | |
5-iododeoxyuridine + phosphate | - |
Mycoplasma hyorhinis | 5-iodouracil + 2-deoxy-D-ribose 1-phosphate | - |
? | |
5-iodouridine + phosphate | - |
Mycoplasma hyorhinis | 5-iodouracil + alpha-D-ribose 1-phosphate | - |
? | |
5-trifluoromethyl-2'-deoxyuridine + phosphate | - |
Mycoplasma hyorhinis | 5-trifluoromethyluracil + 2-deoxy-D-ribose 1-phosphate | - |
? | |
deoxyuridine + phosphate | - |
Mycoplasma hyorhinis | uracil + 2-deoxy-D-ribose 1-phosphate | - |
? | |
additional information | no substrate: cytidine, deoxycytidine, 2',2'-difluoro-2'-deoxycytidine, 2',2'-difluoro-2'-deoxyuridine, uracil arabinoside, thymine arabinoside, (E)-5-(2-bromovinyl)-deoxyuridine, azidothymidine, stavudine, 6-azauridine | Mycoplasma hyorhinis | ? | - |
? | |
thymidine + phosphate | - |
Mycoplasma hyorhinis | thymine + 2-deoxy-D-ribose 1-phosphate | - |
? | |
uridine + phosphate | prefered substrate | Mycoplasma hyorhinis | uracil + alpha-D-ribose 1-phosphate | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
6.1 | - |
5-fluorouridine | pH 7.6, 37°C | Mycoplasma hyorhinis | |
6.4 | - |
5-iodouridine | pH 7.6, 37°C | Mycoplasma hyorhinis | |
8.5 | - |
uridine | pH 7.6, 37°C | Mycoplasma hyorhinis | |
8.6 | - |
phosphate | cosubstrate uridine, pH 7.6, 37°C | Mycoplasma hyorhinis | |
9.5 | - |
5-iododeoxyuridine | pH 7.6, 37°C | Mycoplasma hyorhinis | |
11.9 | - |
5-fluorodeoxyuridine | pH 7.6, 37°C | Mycoplasma hyorhinis | |
17.5 | - |
phosphate | cosubstrate deoxythymidine, pH 7.6, 37°C | Mycoplasma hyorhinis | |
21.6 | - |
thymidine | pH 7.6, 37°C | Mycoplasma hyorhinis | |
24.6 | - |
deoxyuridine | pH 7.6, 37°C | Mycoplasma hyorhinis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000003 | - |
substrate uridine, pH 7.6, 37°C | Mycoplasma hyorhinis | 5-benzylacyclouridine | |
0.000005 | - |
substrate deoxythymidine, pH 7.6, 37°C | Mycoplasma hyorhinis | 5-benzylacyclouridine | |
0.03 | - |
substrate deoxythymidine, pH 7.6, 37°C | Mycoplasma hyorhinis | 7-deazaxanthine | |
0.06 | - |
substrate uridine, pH 7.6, 37°C | Mycoplasma hyorhinis | 7-deazaxanthine | |
0.5 | - |
substrate deoxythymidine, pH 7.6, 37°C | Mycoplasma hyorhinis | 5-chloro-6-(1-[2-iminopyrrolidinyl]methyl)uracil | |
0.5 | - |
substrate uridine, pH 7.6, 37°C | Mycoplasma hyorhinis | 5-chloro-6-(1-[2-iminopyrrolidinyl]methyl)uracil |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
22 | - |
phosphate | cosubstrate deoxythymidine, pH 7.6, 37°C | Mycoplasma hyorhinis | |
22 | - |
phosphate | cosubstrate uridine, pH 7.6, 37°C | Mycoplasma hyorhinis | |
43 | - |
deoxyuridine | pH 7.6, 37°C | Mycoplasma hyorhinis | |
46 | - |
thymidine | pH 7.6, 37°C | Mycoplasma hyorhinis | |
66 | - |
5-iododeoxyuridine | pH 7.6, 37°C | Mycoplasma hyorhinis | |
70 | - |
5-fluorodeoxyuridine | pH 7.6, 37°C | Mycoplasma hyorhinis | |
92 | - |
uridine | pH 7.6, 37°C | Mycoplasma hyorhinis | |
93 | - |
5-iodouridine | pH 7.6, 37°C | Mycoplasma hyorhinis | |
130 | - |
5-fluorouridine | pH 7.6, 37°C | Mycoplasma hyorhinis |