Literature summary for 2.4.2.19 extracted from

Youn, H.S.; Kim, T.G.; Kim, M.K.; Kang, G.B.; Kang, J.Y.; Lee, J.G.; An, J.Y.; Park, K.R.; Lee, Y.; Im, Y.J.; Lee, J.H.; Eom, S.H.
Structural insights into the quaternary catalytic mechanism of hexameric human quinolinate phosphoribosyltransferase, a key enzyme in de novo NAD biosynthesis (2016), Sci. Rep., 6, 19681.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
apoenzyme and in complex with quinolinic acid or nicotinic acid mononucleotide, hanging drop vapor diffusion method, using	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
R161A	the mutation abolishes substrate binding and enzyme activity with a 20% capacity of wild type enzyme	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
quinolinic acid + 5-phospho-alpha-D-ribose 1-diphosphate	Homo sapiens	-	nicotinic acid mononucleotide + diphosphate + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q15274	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
quinolinic acid + 5-phospho-alpha-D-ribose 1-diphosphate	-	Homo sapiens	nicotinic acid mononucleotide + diphosphate + CO2	-	?

Subunits

Subunits	Comment	Organism
hexamer	x-ray crystallography	Homo sapiens

Synonyms

Synonyms	Comment	Organism
QPRT	-	Homo sapiens
quinolinate phosphoribosyltransferase	-	Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C]	Temperature Stability Maximum [°C]	Comment	Organism
83.6	-	melting temperature	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	the enzyme is essential for maintaining the homeostasis of quinolinic acid in the brain	Homo sapiens

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Release 2023.1 (January 2023)