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Literature summary for 2.4.2.19 extracted from
- Crystal structure of quinolinic acid phosphoribosyltransferase from Helicobacter pylori (2006), Proteins, 63, 252-255.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| crystal structure of Hp-QAPRTase with bound quinolinic acid, nicotinic acid mononucleotide, and phthalic acid. Hp-QAPRTase crystals are grown at 20°C using the hanging drop vapor diffusion method | Helicobacter pylori |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate | Helicobacter pylori | essential enzyme in the NAD+ biosynthetic pathway | nicotinate D-ribonucleotide + diphosphate + CO2 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Helicobacter pylori | O25909 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate | essential enzyme in the NAD+ biosynthetic pathway | Helicobacter pylori | nicotinate D-ribonucleotide + diphosphate + CO2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| hexamer | Hp-QAPRTase forms a hexamer with a - trimer of dimers - configuration | Helicobacter pylori |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Hp-QAPRTase | - |
Helicobacter pylori |
| type II quinolinic acid phosphoribosyltransferase | - |
Helicobacter pylori |
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Release 2023.1 (January 2023)
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