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Literature summary for 2.4.2.17 extracted from

  • Cho, Y.; Sharma, V.; Sacchettini, J.C.
    Crystal structure of ATP phosphoribosyltransferase from Mycobacterium tuberculosis (2003), J. Biol. Chem., 278, 8333-8339.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Mycobacterium tuberculosis

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapour diffusion method at 16°C, the apocrystals are obtained using 0.1 M buffer MES pH 6.5 and magnesium sulfate as precipitant, crystals in the presence of AMP and histidine are obtained using 0.1 M sodium citrate pH 5.6, 0.5 M ammonium sulfate and 1 M lithium sulfate with 5 mM AMP and 0.1 mM histidine Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
L-histidine allosteric inhibition, synergistically favored by AMP; feed-back inhibition Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 5-phospho-alpha-D-ribose 1-diphosphate Mycobacterium tuberculosis
-
diphosphate + N-1-(5'-phosphoribosyl)-ATP
-
?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
nickel-nitrilotriacetic acid column, Sephadex G-200 later on Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
Mycobacterium tuberculosis 1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
Mycobacterium tuberculosis diphosphate + N-1-(5'-phosphoribosyl)-ATP
-
?

Subunits

Subunits Comment Organism
dimer active form Mycobacterium tuberculosis
hexamer inactive form, in complex with histidine Mycobacterium tuberculosis