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Literature summary for 2.4.2.17 extracted from

  • Kleeman, J.E.; Parsons, S.M.
    Reverse direction substrate kinetics and inhibition studies on the first enzyme of histidine biosynthesis, adenosine triphosphate phosphoribosyltransferase (1976), Arch. Biochem. Biophys., 175, 687-693.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5-phospho-alpha-D-ribose 1-diphosphate noncompetitive inhibitor with respect to both substrates in the reaction producing ATP and 5-phospho-alpha-D-ribose 1-diphosphate Salmonella enterica subsp. enterica serovar Typhimurium
beta,gamma-methylene-ATP competitive with respect to N-1-(5-phosphoribosyl)-ATP, noncompetitive with respect to diphosphate; inhibitor of the reaction producing ATP and 5-phospho-alpha-D-ribose 1-diphosphate Salmonella enterica subsp. enterica serovar Typhimurium
L-histidine feed-back inhibition; inhibits reverse reaction cooperatively and completely Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 5-phospho-alpha-D-ribose 1-diphosphate Salmonella enterica subsp. enterica serovar Typhimurium first step in histidine biosynthesis diphosphate + N-1-(5'-phosphoribosyl)-ATP
-
?

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Salmonella enterica subsp. enterica serovar Typhimurium

Reaction

Reaction Comment Organism Reaction ID
1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate sequential kinetic mechanism in biosynthetic direction, ordered bi-bi mechanism with ATP binding first to free enzyme and phosphoribosyl-ATP dissociating last from enzyme-product complexes Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
Salmonella enterica subsp. enterica serovar Typhimurium 1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
r
ATP + 5-phospho-alpha-D-ribose 1-diphosphate first step in histidine biosynthesis Salmonella enterica subsp. enterica serovar Typhimurium diphosphate + N-1-(5'-phosphoribosyl)-ATP
-
?
additional information not: ribose 5-phosphate, AMP, ADP, UTP, CTP, GTP Salmonella enterica subsp. enterica serovar Typhimurium ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Salmonella enterica subsp. enterica serovar Typhimurium

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Salmonella enterica subsp. enterica serovar Typhimurium