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Literature summary for 2.4.2.1 extracted from

  • Savarese, T.M.; El Kouni, M.H.
    Isolation and substrate specificity of an adenine nucleoside phosphorylase from adult Schistosoma mansoni (2014), Mol. Biochem. Parasitol., 194, 44-47.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.2.1

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Schistosoma mansoni 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
adenosine + phosphate Schistosoma mansoni
-
 adenine + alpha-D-ribose 1-phosphate
-
 ?
additional information Schistosoma mansoni the enzyme is specific for adenine nucleosides which includes adenosine analogs modified in the aglycone, pentose or both moieties ?
-
 ?

Organism

Organism UniProt Comment Textmining
Schistosoma mansoni
-
-
-

Purification (Commentary)

Purification (Comment) Organism
chromatofocussing column chromatography and gel filtration Schistosoma mansoni

Source Tissue

Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00082
-
 unpurified enzyme, with 5'-deoxy-5'-methylthioadenosine as substrate, at pH 7.0 and 37°C Schistosoma mansoni
0.034
-
 purified enzyme, with 5'-deoxy-5'-methylthioadenosine as substrate, at pH 7.0 and 37°C Schistosoma mansoni

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-deoxyadenosine + phosphate 37% activity compared to adenosine Schistosoma mansoni adenine + 2-deoxy-alpha-D-ribose 1-phosphate
-
 ?
5'-deoxy-5'-iodo-2-fluoroadenosine + phosphate
-
 Schistosoma mansoni 2-fluoroadenine + 5-deoxy-5-iodo-alpha-D-ribose 1-phosphate
-
 ?
5'-deoxy-5'-methylthioadenosine + phosphate 40% activity compared to adenosine Schistosoma mansoni adenine + 5-deoxy-5-methylthio-alpha-D-ribose 1-phosphate
-
 ?
adenosine + phosphate
-
 Schistosoma mansoni adenine + alpha-D-ribose 1-phosphate
-
 ?
adenosine + phosphate 100% activity Schistosoma mansoni adenine + alpha-D-ribose 1-phosphate
-
 ?
additional information the enzyme is specific for adenine nucleosides which includes adenosine analogs modified in the aglycone, pentose or both moieties Schistosoma mansoni ?
-
 ?
additional information no activity with inosine and guanosine Schistosoma mansoni ?
-
 ?

Synonyms

Synonyms Comment Organism
adenine nucleoside phosphorylase
-
 Schistosoma mansoni
ANP
-
 Schistosoma mansoni