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Literature summary for 2.4.1.88 extracted from

  • Elliott, S.P.; Yu, M.; Xu, H.; Haslam, D.B.
    Forssman synthetase expression results in diminished shiga toxin susceptibility: a role for glycolipids in determining host-microbe interactions (2003), Infect. Immun., 71, 6543-6552.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.88

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis, stable expression in and functional complementation of Vero cells, which renders the cells resistant against the toxin Mus musculus
DNA and amino acid sequence determination and analysis, stable expression in and functional complementation of Vero cells, which renders the cells resistant against the toxin Canis lupus familiaris

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus enzyme is responsible for production of Forssman glycolipid, the enzyme modifies the Shiga toxin receptor glycolipids, e.g. globotriaosylceramide, to Forssman glycolipid, which results in highly decreased susceptibility for Shiga toxin, the enzyme expression level is directly related to the level of sensitivity for the cytotoxin ?
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 ?
additional information Canis lupus familiaris enzyme is responsible for production of Forssman glycolipid, the enzyme modifies the Shiga toxin receptor glycolipids, e.g. globotriaosylceramide, to Forssman glycolipid, which results in highly decreased susceptibility for Shiga toxin, the enzyme expression level is directly related to the level of sensitivity for the cytotoxin ?
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 ?

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
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-
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Mus musculus
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no activity in Homo sapiens
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 due to natively occurring inactive gene mutant
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme is responsible for production of Forssman glycolipid, the enzyme modifies the Shiga toxin receptor glycolipids, e.g. globotriaosylceramide, to Forssman glycolipid, which results in highly decreased susceptibility for Shiga toxin, the enzyme expression level is directly related to the level of sensitivity for the cytotoxin Mus musculus ?
-
 ?
additional information enzyme is responsible for production of Forssman glycolipid, the enzyme modifies the Shiga toxin receptor glycolipids, e.g. globotriaosylceramide, to Forssman glycolipid, which results in highly decreased susceptibility for Shiga toxin, the enzyme expression level is directly related to the level of sensitivity for the cytotoxin Canis lupus familiaris ?
-
 ?

Synonyms

Synonyms Comment Organism
Forssman synthetase
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 Mus musculus
Forssman synthetase
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 Canis lupus familiaris
FS
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 Mus musculus
FS
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 Canis lupus familiaris