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Literature summary for 2.4.1.88 extracted from

  • Heissigerova, H.; Breton, C.; Moravcova, J.; Imberty, A.
    Molecular modeling of glycosyltransferases involved in the biosynthesis of blood group A, blood group B, Forssman, and iGb3 antigens and their interaction with substrates (2003), Glycobiology, 13, 377-386.
    View publication on PubMed
Search for more literature for 2.4.1.88

Crystallization (Commentary)

Crystallization (Comment) Organism
structure determination and molecular modeling on the basis of crystal structure of the bovine alpha3GalT, Protein Data Bank code 1K4V Canis lupus familiaris

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+
-
 Canis lupus familiaris

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-galactosamine + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-R Canis lupus familiaris production of the Forssman antigen UDP + N-acetyl-D-galactosaminyl-1,3-N-acetyl-D-galactosaminyl-1,3-D-galactosyl-R
-
 ?

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris Q95158
-
-

Reaction

Reaction Comment Organism Reaction ID
UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-alpha-D-galactosaminyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide catalytic mechanism, substrate binding and active site structure Canis lupus familiaris
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-galactosamine + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-R production of the Forssman antigen Canis lupus familiaris UDP + N-acetyl-D-galactosaminyl-1,3-N-acetyl-D-galactosaminyl-1,3-D-galactosyl-R
-
 ?
UDP-N-acetyl-D-galactosamine + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-R substrate binding mechanism, binding site structures and involved amino acids, binding of the nucleotide sugar requires the residues A263, D206, E297, Q296, W295, and S180, binding of the acceptor sugar involves residues H228, Y259, E298, and others, overview Canis lupus familiaris UDP + N-acetyl-D-galactosaminyl-1,3-N-acetyl-D-galactosaminyl-1,3-D-galactosyl-R
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 ?

Subunits

Subunits Comment Organism
More enzyme structure modeling Canis lupus familiaris

Synonyms

Synonyms Comment Organism
Forss-S
-
 Canis lupus familiaris
More enzyme belongs to the alpha3-Gal(NAc)T 6 family, i.e. GT6 Canis lupus familiaris