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Literature summary for 2.4.1.87 extracted from
- Temperature-dependent cooperativity in donor-acceptor substrate binding to the human blood group glycosyltransferases (2008), Glycobiology, 18, 587-592.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mn2+ | - |
Homo sapiens |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 34483 | - |
2 * 34483 | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-galactose + alpha-L-Fucp-1,2-beta-D-Galp-O(CH2)7CH3 | Homo sapiens | The presence of UDP and Mn2+ has a marked influence on the thermodynamic parameters enthalpy and entropy of association, they decrease, binding to substrate is independent of UDP at physiological temperatures, but cooperatively is observed at lower temperatures | UDP + ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-galactose + alpha-L-Fucp-1,2-beta-D-Galp-O(CH2)7CH3 | The presence of UDP and Mn2+ has a marked influence on the thermodynamic parameters enthalpy and entropy of association, they decrease, binding to substrate is independent of UDP at physiological temperatures, but cooperatively is observed at lower temperatures | Homo sapiens | UDP + ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | 2 * 34483 | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alpha-1,3-galactosyltransferase | - |
Homo sapiens |
| blood group glycosyltransferase | - |
Homo sapiens |
| GTB | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| UDP | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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