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Literature summary for 2.4.1.80 extracted from

  • Chiu, W.H.; Su, W.C.; Li, C.L.; Chen, C.L.; Lin, C.F.
    An increase in glucosylceramide synthase induces Bcl-xL-mediated cell survival in vinorelbine-resistant lung adenocarcinoma cells (2015), Oncotarget, 6, 20513-20524.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
(+/-)-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16739
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell high enzyme expression level and content Homo sapiens
-
CL1-5 cell high enzyme expression level and content Homo sapiens
-
lung adenocarcinoma cell vinorelbine-resistant, high expression of enzyme GCS in lung cancer cells resistant to vinorelbine-induced apoptosis Homo sapiens
-

Synonyms

Synonyms Comment Organism
GCS
-
 Homo sapiens
glucosylceramide synthase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens Vinca alkaloid vinorelbine induces the enzyme in vinorelbine-resitant cells up

General Information

General Information Comment Organism
malfunction genetically silencing the enzyme induces apoptosis with induced ceramide accumulation, accompanied by a decrease in glucosylceramide, and inhibits Bcl-xL function. Simultaneous GCS inhibition and VNR treatment causes a decrease in Bcl-xL expression. Pharmacologically inhibiting enzyme GCS induces ceramide accumulation in vinorelbine-treated A549 and AS2 cells Homo sapiens
additional information vinorelbine works as an anticancer agent by inducing cell growth inhibition and cell apoptosis Homo sapiens
physiological function an increase in glucosylceramide synthase induces Bcl-xL-mediated cell survival in vinorelbine-resistant lung adenocarcinoma cells, potential mechanism of glucosylceramide synthase-mediated Vinca alkaloid vinorelbine resistance in human lung adenocarcinoma cells, overview Homo sapiens