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Literature summary for 2.4.1.80 extracted from

  • Wennekes, T.; van den Berg, R.; Bonger, K.; Donker-Koopman, W.; Ghisaidoobe, A.; van der Marel, G.; Strijland, A.; Aerts, J.; Overkleeft, H.
    Synthesis and evaluation of dimeric lipophilic iminosugars as inhibitors of glucosylceramide metabolism (2009), Tetrahedron Asymmetry, 20, 836-846.
No PubMed abstract available

Cloned(Commentary)

Cloned (Comment) Organism
expressed as recombinant protein Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
N-[5-(adamantan-1-yl-ethoxy)-pentyl]-L-ido-1-deoxynojirimycin
-
Mus musculus
N-[5-(adamantan-1-yl-methoxy)-pentyl]-1-deoxynojirimycin
-
Mus musculus
N-[5-(adamantan-1-yl-methoxy)-pentyl]-L-ido-1-deoxynojirimycin
-
Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
GCS
-
Mus musculus
glucosylceramide synthase
-
Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0001
-
in vivo inhibition of a cell culture Mus musculus N-[5-(adamantan-1-yl-methoxy)-pentyl]-L-ido-1-deoxynojirimycin
0.0002
-
in vivo inhibition of a cell culture Mus musculus N-[5-(adamantan-1-yl-methoxy)-pentyl]-1-deoxynojirimycin
0.0005
-
in vitro inhibition of purified enzyme Mus musculus N-[5-(adamantan-1-yl-methoxy)-pentyl]-1-deoxynojirimycin
0.001
-
in vivo inhibition of a cell culture Mus musculus N-[5-(adamantan-1-yl-ethoxy)-pentyl]-L-ido-1-deoxynojirimycin
0.001
-
in vivo inhibition of a cell culture Mus musculus N-[5-(adamantan-1-yl-ethoxy)-pentyl]-1-deoxynojirimycin
0.005
-
in vitro inhibition of purified enzyme Mus musculus N-[5-(adamantan-1-yl-ethoxy)-pentyl]-L-ido-1-deoxynojirimycin
0.005
-
in vitro inhibition of purified enzyme Mus musculus N-[5-(adamantan-1-yl-ethoxy)-pentyl]-1-deoxynojirimycin
0.005
-
in vivo inhibition of a cell culture Mus musculus N,N'-(5,5'-[adamantan-1,3-diylbis(methylene)]bis(oxy)-bis(pentane-5,1-diyl))-bis(L-ido-1-deoxynojirimycin)
0.01
-
in vitro inhibition of purified enzyme Mus musculus N,N'-(5,5'-[2-(adamantan-1-yl)propane-1,3-diyl]bis-(oxy)bis(pentane-5,1-diyl))-bis(L-ido-1-deoxynojirimycin)
0.01
-
in vitro inhibition of purified enzyme Mus musculus N,N'-(5,5'-[adamantan-1,3-diylbis(methylene)]bis(oxy)-bis(pentane-5,1-diyl))-bis(L-ido-1-deoxynojirimycin)
0.02
-
in vivo inhibition of a cell culture Mus musculus N,N'-(5,5'-[2-(adamantan-1-yl)propane-1,3-diyl]bis-(oxy)bis(pentane-5,1-diyl))-bis(1-deoxynojirimycin)
0.02
-
in vivo inhibition of a cell culture Mus musculus N,N'-(5,5'-[2-(adamantan-1-yl)propane-1,3-diyl]bis-(oxy)bis(pentane-5,1-diyl))-bis(L-ido-1-deoxynojirimycin)
0.02
-
in vivo inhibition of a cell culture Mus musculus N,N'-(5,5'-[adamantan-1,3-diylbis(methylene)]bis(oxy)-bis(pentane-5,1-diyl))-bis(1-deoxynojirimycin)
0.04
-
in vitro inhibition of purified enzyme Mus musculus N,N'-(5,5'-[2-(adamantan-1-yl)propane-1,3-diyl]bis-(oxy)bis(pentane-5,1-diyl))-bis(1-deoxynojirimycin)
0.04
-
in vitro inhibition of purified enzyme Mus musculus N,N'-(5,5'-[adamantan-1,3-diylbis(methylene)]bis(oxy)-bis(pentane-5,1-diyl))-bis(1-deoxynojirimycin)