Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | Homo sapiens | - |
GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P19526 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
dermal microvascular endothelial cell | - |
Homo sapiens | - |
rheumatoid arthritis synovial tissue | - |
Homo sapiens | - |
synovial fibroblast | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | - |
Homo sapiens | GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alpha(1,2)-fucosyltransferase | - |
Homo sapiens |
fucosyltransferase 1 | - |
Homo sapiens |
FUT1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | enzyme activity is increased in arthritis synovial tissue | up |
General Information | Comment | Organism |
---|---|---|
malfunction | blocking enzyme expression in arthritis synovial fibroblasts reduces endothelial cell tube formation | Homo sapiens |
physiological function | the enzyme is responsible for synthesis of the H blood group and Lewis y antigens | Homo sapiens |