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Literature summary for 2.4.1.62 extracted from

  • Wang, Y.; Maeda, Y.; Liu, Y.S.; Takada, Y.; Ninomiya, A.; Hirata, T.; Fujita, M.; Murakami, Y.; Kinoshita, T.
    Cross-talks of glycosylphosphatidylinositol biosynthesis with glycosphingolipid biosynthesis and ER-associated degradation (2020), Nat. Commun., 11, 860 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.62

Activating Compound

Activating Compound Comment Organism Structure
lactosylceramide presence of lactosylceramide is required for B3GALT4 to transfer galalctose to glycosylphosphatidylinositol Homo sapiens

Protein Variants

Protein Variants Comment Organism
D175A overexpression of the mutant and -D291A does not rescue galactosylation deficiency of a knockout strain Homo sapiens
D176A overexpression of the mutant and -D291A does not rescue galactosylation deficiency of a knockout strain Homo sapiens
D177A overexpression of the mutant and -D291A does not rescue galactosylation deficiency of a knockout strain Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O96024 isoform B3GALT4
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information GM1 ganglioside synthase B3GALT4 additionally functions in transferring galactose to the N-acetylgalactosamine side-chain of GPI. B3GALT4 requires lactosylceramide for the efficient GPI side-chain galactosylation Homo sapiens ?
-
-
UDP-galactose + ganglioside GA2
-
 Homo sapiens UDP + ganglioside GA1
-
 ?
UDP-galactose + N-acetyl-Gal-glycosylphosphatidylinositol
-
 Homo sapiens UDP + ?
-
 ?

Synonyms

Synonyms Comment Organism
B3GALT4
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function glycosylphosphatidylinositol bearing non-galactosylated GalNAc side-chain increases from 70% to 81% after KO of B3GALT4, however, 18% of the GPI still have one hexose and a GalNAc side-chain Homo sapiens