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Literature summary for 2.4.1.274 extracted from

  • Shirane, K.; Kuji, R.; Tareyanagi, C.; Sato, T.; Kobayashi, Y.; Furukawa, S.; Murata, T.; Kubota, S.; Ishikawa, Y.; Segawa, K.; Furukawa, K.
    Gene expression levels of beta4-galactosyltransferase 5 correlate with the tumorigenic potentials of B16-F10 mouse melanoma cells (2014), Glycobiology, 24, 532-541.
    View publication on PubMed
Search for more literature for 2.4.1.274

Application

Application Comment Organism
medicine the amounts of Lac-Cer synthesized by isoform beta4GalT5 correlate with the tumorigenic potentials of malignantly transformed cells Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-alpha-D-galactose + glucosylceramide Mus musculus
-
 UDP + lactosylceramide
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9JMK0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B16-F10 cell
-
 Mus musculus
-
B16-F10 cell melanoma cell Mus musculus
-
MEF cell
-
 Mus musculus
-
melanoma cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-alpha-D-galactose + glucosylceramide
-
 Mus musculus UDP + lactosylceramide
-
 ?

Synonyms

Synonyms Comment Organism
beta4-galactosyltransferase 5
-
 Mus musculus
beta4GalT5
-
 Mus musculus
Lac-Cer synthase
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus gene expression increases by 2-3fold upon malignant transformation of cells up

General Information

General Information Comment Organism
physiological function the amounts of Lac-Cer and ganglioside GM3 are significantly less in a stable clone E5 whose beta4GalT5 gene expression level is reduced to 35% than in a control clone C1 by transfection of its antisense cDNA. The average tumor size and average number of colonies formed with clone E5 are decreased to 44 and 49%, respectively, of those formed with clone C1. The numbers and sizes of colonies formed in the soft agarose gels, and the volumes of tumors formed in athymic mice with fibroblasts from wild type, heterozygous and homozygous beta4GalT5-knockout mouse embryos upon transformation with the polyoma virus oncogene correlate with the beta4GalT5 gene dosage Mus musculus