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Literature summary for 2.4.1.264 extracted from

  • Katzen, F.; Ferreiro, D.U.; Oddo, C.G.; Ielmini, M.V.; Becker, A.; Pühler, A.; Ielpi, L.
    Xanthomonas campestris pv. campestris gum mutants: effects on xanthan biosynthesis and plant virulence (1998), J. Bacteriol., 180, 1607-1617.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
synthesis the enzyme is involved in biosynthesis of xanthan, an industrially important exopolysaccharide Xanthomonas campestris

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-glucuronate + D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphosphoundecaprenol Xanthomonas campestris the enzyme is involved in biosynthesis of xanthan UDP + GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphosphoundecaprenol
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Organism

Organism UniProt Comment Textmining
Xanthomonas campestris
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 pv. campestris
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucuronate + D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphosphoundecaprenol the enzyme is involved in biosynthesis of xanthan Xanthomonas campestris UDP + GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphosphoundecaprenol
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 ?
UDP-glucuronate + D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphosphoundecaprenol
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 Xanthomonas campestris UDP + GlcA-beta-(1-2)-D-Man-alpha-(1-3)-D-Glc-beta-(1-4)-D-Glc-alpha-1-diphosphoundecaprenol
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 ?

Synonyms

Synonyms Comment Organism
gumK
-
 Xanthomonas campestris

General Information

General Information Comment Organism
malfunction from the biochemical analysis of a defined set of Xanthomonas campestris gum mutants, experimental data are reported for assigning functions to the products of the gum genes. Inactivation of gumK completely abolishes in vitro polymer formation. Permeabilized cells are incubated with UDP-glucose, GDP-mannose, and UDP-glucuronic acid, one of them labeled in the sugar moiety. Accumulating intermediates are analysed. The gumK deletion strain produces a very low amount of polymer in vivo (polytrimer). Mutations in gumK gene has less effect on the amount of in vitro produced polysaccharide Xanthomonas campestris
physiological function the enzyme is involved in biosynthesis of xanthan Xanthomonas campestris