Cloned (Comment) | Organism |
---|---|
full length and functional human mOGT is difficult to be expressed in Escherichia coli, truncated mOGT recombinant (C-654) is constructed and expressed | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.16 | - |
YSDSPSTST | - |
Homo sapiens | |
0.17 | - |
UDP-GlcNAc | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
73000 | - |
theoretical | Homo sapiens |
75000 | - |
highly purified C-654, truncated mOGT recombinant | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | transfer of O-linked GlcNAc to serine/threonine residues of a variety of substrate proteins, including nuclear pore proteins, transcription factors, and proteins implicated in diabetes and neurodegenerative disorders | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | enzyme for protein post-translational modifications | Homo sapiens |
Purification (Comment) | Organism |
---|---|
Ni2+-affinity chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | transfer of O-linked GlcNAc to serine/threonine residues of a variety of substrate proteins, including nuclear pore proteins, transcription factors, and proteins implicated in diabetes and neurodegenerative disorders | Homo sapiens | ? | - |
? | |
UDP-GlcNAc + YSDSPSTST | coupled enzyme assay of C-654 | Homo sapiens | YSDSP-(GlcNAc)STST + UDP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
mOGT | - |
Homo sapiens |
O-linked GlcNAc transferase | - |
Homo sapiens |
OGT | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.76 | - |
UDP-GlcNAc | - |
Homo sapiens | |
2.48 | - |
YSDSPSTST | - |
Homo sapiens |