Literature summary for 2.4.1.255 extracted from

Maerz, P.; Stetefeld, J.; Bendfeldt, K.; Nitsch, C.; Reinstein, J.; Shoeman, R.L.; Dimitriades-Schmutz, B.; Schwager, M.; Leiser, D.; Ozcan, S.; Otten, U.; Ozbek, S.
Ataxin-10 interacts with O-linked beta-N-acetylglucosamine transferase in the brain (2006), J. Biol. Chem., 281, 20263-20270.

Search for more literature for 2.4.1.255

Activating Compound

Activating Compound	Comment	Organism	Structure
Ataxin-10	Atx-10 increases OGT activity 2fold	Rattus norvegicus
Ataxin-10	Atx-10 increases OGT activity 2fold	Homo sapiens

Application

Application	Comment	Organism
medicine	the neurodegenerative disease protein ataxin-10 (Atx-10) is associated with cytoplasmic OGT p110 in the brain	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	shorter OGT p78 splice form	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Rattus norvegicus	5829	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
78000	-	x * 110000 + x * 78000	Rattus norvegicus
78000	-	x * 110000 + x * 78000	Homo sapiens
110000	-	x * 110000 + x * 78000	Rattus norvegicus
110000	-	x * 110000 + x * 78000	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O15294	-	-
Rattus norvegicus	P56558	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-
brain	-	Homo sapiens	-
heart	110 kDa subunit	Rattus norvegicus	-
liver	78 kDa subunit and 110 kDa subunit	Rattus norvegicus	-
lung	110 kDa subunit	Rattus norvegicus	-
muscle	110 kDa subunit	Rattus norvegicus	-
pancreas	-	Homo sapiens	-
pancreas	78 kDa subunit and 110 kDa subunit	Rattus norvegicus	-
PC-12 cell	-	Rattus norvegicus	-
spleen	78 kDa subunit and 110 kDa subunit	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDP-GlcNAc + CKII peptide	PGGSTPVSSANMM	Rattus norvegicus	UDP + N-acetylglucosaminyl-CKII alpha-peptide	-	?

Subunits

Subunits	Comment	Organism
?	x * 110000 + x * 78000	Rattus norvegicus
?	x * 110000 + x * 78000	Homo sapiens

Synonyms

Synonyms	Comment	Organism
O-linked beta-N-acetylglucosamine transferase	-	Rattus norvegicus
O-linked beta-N-acetylglucosamine transferase	-	Homo sapiens
OGT	-	Rattus norvegicus
OGT	-	Homo sapiens
OGT p110	-	Rattus norvegicus
OGT p110	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)