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Literature summary for 2.4.1.225 extracted from

  • Busse, M.; Kusche-Gullberg, M.
    In vitro polymerization of heparan sulfate backbone by the EXT proteins (2003), J. Biol. Chem., 278, 41333-41337.
    View publication on PubMed

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
80000
-
EXT2, gel filtration Homo sapiens
160000
-
EXT1, and coexpressed EXT1/EXT2, gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
recombinant enzymes EXT1 and EXT2 lacking transmembrane domains
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information EXT1 has both GlcNAc transferase activity of EC 2.4.1.224 and GlcA transferase activity of EC 2.4.1.225, EXT2 only has low activity of EC 2.4.1.225, coexpression of EXT1 and EXT2 yields high activity of EC 2.4.1.225 and low activity of EC 2.4.1.224 Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
dimer 2 * 80000, EXT1, calculated, 1 * 80000 + 1 * 80000, EXT1/EXT2 heterodimer, calculated Homo sapiens
monomer 80000, EXT2, calculated Homo sapiens

pI Value

Organism Comment pI Value Maximum pI Value
Homo sapiens EXT2, calculated
-
6
Homo sapiens heterodimer EXT1/EXT2, calculated
-
7.5
Homo sapiens EXT1, calculated
-
9