Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum membrane | Ext1 and Ext2 are type II transmembrane glycoproteins | Mus musculus | 5789 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | the Ext1/Ext2 complex possesses higher glycosyltransferase activity than Ext1 or Ext2 alone | ? | - |
? | |
additional information | Mus musculus BALB/c | the Ext1/Ext2 complex possesses higher glycosyltransferase activity than Ext1 or Ext2 alone | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
gene sext1 and ext2 | - |
Mus musculus BALB/c | - |
gene sext1 and ext2 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | Ext1 and Ext2 are type II transmembrane glycoproteins | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
osteosarcoma cell | FBJ, highly metastatic mouse osteosarcoma FBJ-LL cells and the poorly metastatic FBJ-S1 cells are produced from a FBJ virus-induced osteosarcoma | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the Ext1/Ext2 complex possesses higher glycosyltransferase activity than Ext1 or Ext2 alone | Mus musculus | ? | - |
? | |
additional information | the Ext1/Ext2 complex possesses higher glycosyltransferase activity than Ext1 or Ext2 alone | Mus musculus BALB/c | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Exostosin1 | - |
Mus musculus |
Exostosin2 | - |
Mus musculus |
EXT1 | - |
Mus musculus |
EXT2 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | a reduction in either Ext1 or Ext2 can cause a reduction in heparan sulfate biosynthesis, overview. Suppression of Ext1 by siRNA in FBJ-S1 cells results in the decreased expression of heparan sulfate and enhanced motility | Mus musculus |
physiological function | Ext1 and Ext2 are tumor suppressors. In the biosynthesis of heparan sulfate, after the attachment of a GlcNAc residue to GlcA-Gal-Gal-Xyl, Ext1 and Ext2 catalyze the subsequent elongation of glycosaminoglycans by alternately adding GlcA and GlcNAc to the end of the growing chain. Involvement of Ext1 and heparanase in migration of FBJ osteosarcoma cells, overview | Mus musculus |