Application | Comment | Organism |
---|---|---|
diagnostics | Pofut1 overexpression clinically correlates with the unfavorable survival and high disease recurrence in hepatocellular carcinoma | Homo sapiens |
medicine | an aberrant activated Pofut1-Notch pathway is involved in hepatocellular carcinoma progression, and blockage of this pathway can be a promising strategy for the therapy of hepatocellular carcinomas | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
quantitative real-time PCR enzyme expression analysis | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme catalyzes the addition of O-linked fucose to the epidermal growth factor-like repeats of Notch | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9H488 | gene POFUT1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEP-3B cell | - |
Homo sapiens | - |
Hep-G2 cell | - |
Homo sapiens | - |
hepatocellular carcinoma cell | analysis of enzyme expression in 8 HCC cell lines and 253 human HCC tissues, overview | Homo sapiens | - |
Huh7 cell | - |
Homo sapiens | - |
MHCC-97L cell | - |
Homo sapiens | - |
SMMC-7721 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme catalyzes the addition of O-linked fucose to the epidermal growth factor-like repeats of Notch | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Pofut1 | - |
Homo sapiens |
protein O-fucosyltransferase 1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | knockdown and overexpression of Pofut1 inhibits and accelerates the growth, migration and invasion of hepatocellular carcinoma cells, respectively | Homo sapiens |
physiological function | the enzyme catalyzes the addition of O-linked fucose to the epidermal growth factor-like repeats of Notch. Pofut1 overexpression accelerates cell proliferation and migration in hepatocellular carcinoma cells and it promotes the binding of Notch ligand Dll1 to Notch receptor, and hence activates Notch signaling pathway in hepatocellular carcinoma cells | Homo sapiens |