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Literature summary for 2.4.1.221 extracted from

  • Okamura, Y.; Saga, Y.
    Pofut1 is required for the proper localization of the Notch receptor during mouse development (2008), Mech. Dev., 125, 663-673.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
embryo presomitic mesoderm Mus musculus
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Synonyms

Synonyms Comment Organism
Pofut1
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Mus musculus
protein O-fucosyltransferase 1
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Mus musculus

General Information

General Information Comment Organism
malfunction Pofut1-null mouse shows a similar phenotype to the RBP-Jk null mouse. Cardiac development in the Pofut1-/- mice is severely affected in valve formation, which is characterized in the lack of mesenchymal cells as seen in RBP-Jk null embryos and embryonic development is arrested at E9.0. Pofut1-null cells do not possess normally localized Notch1 receptors. Abnormal accumulation of the Notch1 receptor in the endoplasmic reticulum and cytoplasm in Pofut1-null mouse embryos Mus musculus
physiological function Pofut1 is required for Notch signaling upstream of NICD1 Mus musculus