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Literature summary for 2.4.1.221 extracted from

  • Stanley, P.; Guidos, C.J.
    Regulation of Notch signaling during T- and B-cell development by O-fucose glycans (2009), Immunol. Rev., 230, 201-215.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface OFUT1 may be a chaperone of Notch that is necessary for retaining Notch at the cell surface once it has traversed the secretory pathway Drosophila sp. (in: flies) 9986
-
endoplasmic reticulum
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Mus musculus 5783
-
endoplasmic reticulum OFUT1 may be a chaperone of Notch that is necessary for escorting Notch out of the endoplasmic reticulum Drosophila sp. (in: flies) 5783
-

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
-
-
Drosophila sp. (in: flies)
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CHO cell
-
Cricetulus griseus
-
embryonic stem cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GDP-L-fucose + Notch Pofut1 transfers fucose in the endoplasmic reticulum, transfers fucose to Ser or Thr residues of epidermal growth factor-like repeats Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
O-fucosyltransferase 1
-
Cricetulus griseus
O-fucosyltransferase 1
-
Drosophila sp. (in: flies)
O-fucosyltransferase 1
-
Mus musculus
OFUT1
-
Drosophila sp. (in: flies)
Pofut1
-
Cricetulus griseus
Pofut1
-
Mus musculus

General Information

General Information Comment Organism
malfunction CHO cells lacking Pofut1 express Notch receptors on the cell surface at similar levels to wild-type cells Cricetulus griseus
malfunction deletion of Pofut1 leads to global defects in Notch signaling and death of mice at E9.5, with a phenotype consistent with inactivation of signaling by the four Notch receptors. Embryonic stem cells lacking Pofut1 express Notch receptors on the cell surface at similar levels to wild-type cells. In mouse somites, there is evidence of altered Notch trafficking in the absence of Pofut1, consistent with reduced cell surface expression Mus musculus