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Literature summary for 2.4.1.22 extracted from

  • Ebner, K.E.
    Lactose synthetase (1973), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 9, 363-377.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
2-deoxy-D-glucose 0.4 M, 68% inhibition Mammalia
Ca2+ above 4 mM Mammalia
D-arabinose 0.4 M, 13% inhibition Mammalia
D-ribose 0.4 M, 59% inhibition Mammalia
D-xylose 0.4 M, 36% inhibition Mammalia
L-arabinose 0.4 M, 54% inhibition Mammalia
L-sorbose 0.4 M, 45% inhibition Mammalia
L-Xylose 0.4 M, 16% inhibition Mammalia
Mg2+ above 4 mM Mammalia
additional information alpha-lactalbumin strongly inhibits the transfer of galactose to free N-acetylglucosamine Mammalia
UDPglucose
-
Mammalia

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Mammalia
additional information
-
additional information
-
Homo sapiens
additional information
-
additional information
-
Bos taurus
1400
-
glucose reaction in absence of alpha-lactalbumin Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+
-
Homo sapiens
Mn2+
-
Bos taurus
Mn2+ not replaceable by Mg2+, Ca2+ Mammalia

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
75000
-
gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Capra hircus
-
-
-
Homo sapiens
-
-
-
Mammalia
-
female
-
Mus musculus
-
-
-
Ovis aries
-
-
-
Sus scrofa
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Mammalia
glycoprotein
-
Bos taurus
glycoprotein the glycoprotein contains 1.1% sialic acid, 5.03% galactosamine, 2.47% glucosamine, 2.36% galactose, 0.87% mannose and 0.87% fucose Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
mammary gland
-
Mammalia
-
mammary gland
-
Mus musculus
-
mammary gland
-
Homo sapiens
-
mammary gland
-
Bos taurus
-
milk
-
Bos taurus
-
milk
-
Ovis aries
-
milk
-
Capra hircus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dUDPgalactose + D-glucose
-
Mammalia lactose + dUDP
-
?
dUDPgalactose + D-glucose dUDPgalactose is 80% as effective as UDP-D-galactose Bos taurus lactose + dUDP
-
?
UDPgalactose + cellobiose 7.5% of the activity of glucose Bos taurus ?
-
?
UDPgalactose + D-glucose
-
Mammalia lactose + UDP
-
?
UDPgalactose + D-glucose
-
Mus musculus lactose + UDP
-
?
UDPgalactose + D-glucose
-
Homo sapiens lactose + UDP
-
?
UDPgalactose + D-glucose
-
Sus scrofa lactose + UDP
-
?
UDPgalactose + D-glucose
-
Ovis aries lactose + UDP
-
?
UDPgalactose + D-glucose
-
Capra hircus lactose + UDP
-
?
UDPgalactose + D-glucose the galactosyl transferase can catalyze the transfer of galactose to glucose to form lactose in the absence of alpha-lactalbumin provided the glucose concentration is high Bos taurus lactose + UDP
-
?