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Literature summary for 2.4.1.212 extracted from
- Regulation of hyaluronan synthesis by vasodilatory prostaglandins. Implications for atherosclerosis (2007), Thromb. Haemost., 98, 287-295.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| interleukin-1beta | - |
Mammalia | |
| PDGF-BB | - |
Mammalia | |
| prostacyclin | - |
Mammalia |  |
| prostaglandin E2 | - |
Mammalia | |
| prostaglandin F2alpha | - |
Mammalia | |
| prostaglandin I2 | - |
Mammalia | |
| TGFbeta1 | - |
Mammalia | |
| TNFalpha | - |
Mammalia |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Mammalia |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-methylesculetin | - |
Mammalia | |
| 4-Methylumbelliferone | - |
Mammalia | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | - |
Mammalia | 5886 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan] | Mammalia | - |
UDP + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan] | - |
? | |
| UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan] | Mammalia | - |
UDP + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan] | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mammalia | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast | - |
Mammalia | - |
| leukocyte | - |
Mammalia | - |
| mesangial cell | - |
Mammalia | - |
| oocyte | - |
Mammalia | - |
| pericardial mesothelium | - |
Mammalia | - |
| renal glomerulus | - |
Mammalia | - |
| synoviocyte | - |
Mammalia | - |
| uterine cervix | - |
Mammalia | - |
| vascular smooth muscle cell | - |
Mammalia | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan] | - |
Mammalia | UDP + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan] | - |
? | |
| UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan] | - |
Mammalia | UDP + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan] | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HAS | - |
Mammalia |
| hyaluronan synthase | - |
Mammalia |
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Release 2023.1 (January 2023)
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