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Literature summary for 2.4.1.198 extracted from

  • Yadav, A.; Singh, S.L.; Yadav, B.; Komath, S.S.
    Saccharomyces cerevisiae Gpi2, an accessory subunit of the enzyme catalyzing the first step of glycosylphosphatidylinositol (GPI) anchor biosynthesis, selectively complements some of the functions of its homolog in Candida albicans (2014), Glycoconj. J., 31, 497-507.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
gene GPI2 encodes for one of the six accessory subunits of the GPI-N-acetylglucosaminyltransferase complex Saccharomyces cerevisiae
gene GPI2 encodes for one of the six accessory subunits of the GPI-N-acetylglucosaminyltransferase complex Candida albicans

Protein Variants

Protein Variants Comment Organism
additional information recombinant expression of Candida albicans GPI2 subunit in a Saccharomyces cerevisiae GPI2 subunit conditional lethal mutant cannot restore its growth defects. In mutants where CaGPI19 is downregulated, a downregulation of CaGPI2 is unable to restore CaERG11 levels, suggesting that CaGpi19, rather than CaGpi2 is the major partner in the cross-talk with CaErg11 Candida albicans
additional information Saccharomyces cerevisiae Gpi2, an accessory subunit of the enzyme catalyzing the first step of glycosylphosphatidylinositol (GPI) anchor biosynthesis, selectively complements some of the functions of its homologue in Candida albicans Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Candida albicans Q5A6L6 enzyme complex subunit GPI2
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Saccharomyces cerevisiae
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-
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Synonyms

Synonyms Comment Organism
GPI-GnT
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 Saccharomyces cerevisiae
GPI-GnT
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 Candida albicans
GPI-N-acetylglucosaminyltransferase
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 Saccharomyces cerevisiae
GPI-N-acetylglucosaminyltransferase
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 Candida albicans
GPI2
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 Candida albicans

General Information

General Information Comment Organism
malfunction recombinant expression of Candida albicans GPI2 subunit in a Scaccharomyces cerevisiae GPI2 subunit conditional lethal mutant cannot restore its growth defects Saccharomyces cerevisiae
malfunction Saccharomyces cerevisiae Gpi2, an accessory subunit of the enzyme catalyzing the first step of glycosylphosphatidylinositol (GPI) anchor biosynthesis, selectively complements some of the functions of its homologue in Candida albicans Candida albicans
physiological function Saccharomyces cerevisiae enzyme subunit Gpi2 is an accessory subunit of the enzyme that catalyzes the first step of glycosylphosphatidylinositol (GPI) anchor biosynthesis. Saccharomyces cerevisiae enzyme subunit Gpi2 subunit physically interacts with and negatively modulates Ras signaling, while enzyme subunit Gpi2 from Candida albicans is a positive modulator of Ras signaling Saccharomyces cerevisiae
physiological function the GPI-Nacetylglucosaminyltransferase (GPI-GnT) enzyme complex catalyzes the first and committing step of the pathway in Candida albicans involving transfer of N-acetylglucosamine from UDP-GlcNAc to phosphatidylinositol. Saccharomyces cerevisiae subunit Gpi2 enzyme subunit physically interacts with and negatively modulates Ras signaling, while enzyme subunit Gpi2 from Candida albicans is a positive modulator of Ras signaling. The effect of Candida albicans GPI2 subunit on sterol biosynthesis Candida albicans is independent of its interaction with the GPI-GnT enzyme complex and Ras signaling pathways Candida albicans