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Literature summary for 2.4.1.186 extracted from

  • Zeqiraj, E.; Tang, X.; Hunter, R.; Garcia-Rocha, M.; Judd, A.; Deak, M.; Von Wilamowitz-Moellendorff, A.; Kurinov, I.; Guinovart, J.; Tyers, M.; Sakamoto, K.; Sicheri, F.
    Structural basis for the recruitment of glycogen synthase by glycogenin (2014), Proc. Natl. Acad. Sci. USA, 111, E2831-E2840.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
glycogen synthase-glycogenin enzyme complex, PDB ID 4QLB, GS-N interaction surface, overview Caenorhabditis elegans

Protein Variants

Protein Variants Comment Organism
additional information construction of a truncated enzyme version CeGN34. The CeGNDELTAC mutant is defective for interaction with glycogen synthase CeGS Caenorhabditis elegans
Y194F site-directed mutagenesis, inactive mutant Caenorhabditis elegans

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-alpha-D-glucose + glycogenin self-glucosylation of the glycosyltransferase glycogenin Caenorhabditis elegans UDP + alpha-D-glucosylglycogenin
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Subunits

Subunits Comment Organism
More glycogenin is a member of the GT8 family of glycosyltransferases with a GT-A architecture containing an N-terminal catalytic domain with a single Rossmann fold that operates as an obligate dimer. The core catalytic domain is followed by a C-terminal extension of variable length and undefined structure. Oligomerization of glycogenin and glycogen synthase from Caenorhabditis elegans enhances binding through an avidity effect Caenorhabditis elegans

Synonyms

Synonyms Comment Organism
CeGN
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Caenorhabditis elegans

General Information

General Information Comment Organism
evolution glycogenin is a member of the GT8 family of glycosyltransferases with a GT-A architecture Caenorhabditis elegans
additional information interaction and binding of wild-type full-length enzyme and truncated mutant CeGN34 to glycogen synthase, the CeGS-CeGN34 interaction is required for glycogen formation, overview Caenorhabditis elegans