Cloned (Comment) | Organism |
---|---|
gene CSGALNACT1, quantitative real-time PCR enzyme expression analysis | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8TDX6 | gene csgalnact1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cartilage | articular | Homo sapiens | - |
chondrocyte | - |
Homo sapiens | - |
additional information | immunohistochemic analysis of enzyme content and localization, overview | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
chondroitin sulphate N-acetylgalactosaminyltransferase 1 | - |
Homo sapiens |
CSGalNAcT-1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the enzyme is downregulated in Kashin-Beck disease (KBD), an endemic degenerative osteoarthritis, and in primary osteoarthritis, both associated with extracellular matrix degradation | down |
General Information | Comment | Organism |
---|---|---|
malfunction | the enzyme is downregulated in Kashin-Beck disease (KBD), an endemic degenerative osteoarthritis, and in primary osteoarthritis, both associated with extracellular matrix degradation. Enzyme CSGalNAcT-1 may be involved in the damage of articular cartilage of Kashin-Beck disease and osteoarthritis by regulating Hapln-1 in the Wnt/beta-catenin signalling pathway. Alterations of involved enzyme expressions in CSGalNAcT gene network in case of Kashin-Beck disease and osteoarthritis | Homo sapiens |
physiological function | chondroitin sulfate N-acetylgalactosaminyl-transferase-1 is an essential enzyme in chondroitin sulfate metabolism and participates in chondroitin sulfate chain formation of aggrecan, and plays an important role in degenerative extracellular matrix of cartilage | Homo sapiens |