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Literature summary for 2.4.1.17 extracted from
- Identification and preliminary characterization of UDP-glucuronosyltransferases catalyzing formation of ethyl glucuronide (2014), Anal. Bioanal. Chem., 406, 2325-2332.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| kaempferol | the formation of ethylglucuronoside is inhibited by the flavonoids for all enzymes except for UGT2B15, mechanism-based inhibition; the formation of ethylglucuronoside is inhibited by the flavonoids for all UGT enzymes except for UGT2B15, mechanism-based inhibition; the formation of ethylglucuronoside is inhibited by the flavonoids for all UGT enzymes except for UGT2B15, mechanism-based inhibition; the formation of ethylglucuronoside is inhibited by the flavonoids for all UGT enzymes except for UGT2B15, mechanism-based inhibition; the formation of ethylglucuronoside is inhibited by the flavonoids for all UGT enzymes except for UGT2B15, mechanism-based inhibition; the formation of ethylglucuronoside is inhibited by the flavonoids for all UGT enzymes except for UGT2B15, mechanism-based inhibition; the formation of ethylglucuronoside is inhibited by the flavonoids for all UGT enzymes except for UGT2B15, mechanism-based inhibition | Homo sapiens |  |
| additional information | the formation of ethylglucuronoside is inhibited by the flavonoids kaempferol and quercetin for all enzymes except for UGT2B15, mechanism-based inhibition | Homo sapiens | |
| quercetin | the formation of ethylglucuronoside is inhibited by the flavonoids for all enzymes except for UGT2B15, mechanism-based inhibition; the formation of ethylglucuronoside is inhibited by the flavonoids for all UGT enzymes except for UGT2B15, mechanism-based inhibition; the formation of ethylglucuronoside is inhibited by the flavonoids for all UGT enzymes except for UGT2B15, mechanism-based inhibition; the formation of ethylglucuronoside is inhibited by the flavonoids for all UGT enzymes except for UGT2B15, mechanism-based inhibition; the formation of ethylglucuronoside is inhibited by the flavonoids for all UGT enzymes except for UGT2B15, mechanism-based inhibition; the formation of ethylglucuronoside is inhibited by the flavonoids for all UGT enzymes except for UGT2B15, mechanism-based inhibition; the formation of ethylglucuronoside is inhibited by the flavonoids for all UGT enzymes except for UGT2B15, mechanism-based inhibition | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | Michaelis-Menten kinetics, overview | Homo sapiens | |
| 8.03 | - |
ethanol | pH 7.4, 37°C, enzyme UGT2B15 | Homo sapiens | |
| 10.33 | - |
ethanol | pH 7.4, 37°C, enzyme UGT1A1 | Homo sapiens | |
| 12.05 | - |
ethanol | pH 7.4, 37°C, enzyme UGT1A4 | Homo sapiens | |
| 21.46 | - |
ethanol | pH 7.4, 37°C, enzyme UGT1A6 | Homo sapiens | |
| 26.17 | - |
ethanol | pH 7.4, 37°C, enzyme UGT1A9 | Homo sapiens | |
| 32.41 | - |
ethanol | pH 7.4, 37°C, enzyme UGT2B7 | Homo sapiens | |
| 35.07 | - |
ethanol | pH 7.4, 37°C, enzyme UGT2B10 | Homo sapiens | |
| 40.04 | - |
ethanol | pH 7.4, 37°C, enzyme UGT1A3 | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | enzyme ion suppression | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-glucuronate + ethanol | Homo sapiens | - |
UDP + ethyl beta-D-glucuronoside | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O60656 | UGT1A9; gene UGT1A9 | - |
| Homo sapiens | P16662 | UGT2B7; gene UGT2B7 | - |
| Homo sapiens | P19224 | UGT1A6; gene UGT1A6 | - |
| Homo sapiens | P22309 | UGT1A1 | - |
| Homo sapiens | P22310 | UGT1A4; gene UGT1A4 | - |
| Homo sapiens | P35503 | UGT1A3; gene UGT1A3 | - |
| Homo sapiens | P36537 | UGT2B10; gene UGT2B10 | - |
| Homo sapiens | P54855 | UGT2B15; gene UGT2B15 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | recombinant | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
Vmax values for all enzymes with ethanol | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-glucuronate + acceptor | - |
Homo sapiens | UDP + acceptor beta-D-glucuronoside | - |
? | |
| UDP-glucuronate + ethanol | - |
Homo sapiens | UDP + ethyl beta-D-glucuronoside | - |
? | |
| UDP-glucuronate + ethanol | high activity | Homo sapiens | UDP + ethyl beta-D-glucuronoside | - |
? | |
| UDP-glucuronate + ethanol | highest activity with enzymes UGT1A9 and UGT2B7 | Homo sapiens | UDP + ethyl beta-D-glucuronoside | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| UDP-glucuronosyltransferase | - |
Homo sapiens |
| UGT1A1 | - |
Homo sapiens |
| UGT1A3 | - |
Homo sapiens |
| UGT1A4 | - |
Homo sapiens |
| UGT1A6 | - |
Homo sapiens |
| UGT1A9 | - |
Homo sapiens |
| UGT2B10 | - |
Homo sapiens |
| UGT2B15 | - |
Homo sapiens |
| UGT2B7 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.002 | - |
quercetin | pH 7.4, 37°C, enzyme UGT1A1 | Homo sapiens | |
| 0.0099 | - |
kaempferol | pH 7.4, 37°C, enzyme UGT2B10 | Homo sapiens | |
| 0.0112 | - |
kaempferol | pH 7.4, 37°C, enzyme UGT2B7 | Homo sapiens | |
| 0.015 | - |
quercetin | pH 7.4, 37°C, enzyme UGT1A3 | Homo sapiens | |
| 0.0301 | - |
quercetin | pH 7.4, 37°C, enzyme UGT1A9 | Homo sapiens | |
| 0.0326 | - |
kaempferol | pH 7.4, 37°C, enzyme UGT1A6 | Homo sapiens | |
| 0.0372 | - |
kaempferol | pH 7.4, 37°C, enzyme UGT1A1 | Homo sapiens | |
| 0.044 | - |
kaempferol | pH 7.4, 37°C, enzyme UGT1A9 | Homo sapiens | |
| 0.0623 | - |
kaempferol | pH 7.4, 37°C, enzyme UGT1A3 | Homo sapiens | |
| 0.0711 | - |
quercetin | pH 7.4, 37°C, enzyme UGT1A6 | Homo sapiens | |
| 0.0931 | - |
quercetin | pH 7.4, 37°C, enzyme UGT2B10 | Homo sapiens | |
| 0.1132 | - |
quercetin | pH 7.4, 37°C, enzyme UGT1A4 | Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.003 | - |
pH 7.4, 37°C, enzyme UGT1A1 | Homo sapiens | quercetin | |
| 0.0104 | - |
pH 7.4, 37°C, enzyme UGT2B10 | Homo sapiens | kaempferol | |
| 0.0138 | - |
pH 7.4, 37°C, enzyme UGT2B7 | Homo sapiens | kaempferol | |
| 0.0149 | - |
pH 7.4, 37°C, enzyme UGT1A6 | Homo sapiens | kaempferol | |
| 0.0178 | - |
pH 7.4, 37°C, enzyme UGT1A3 | Homo sapiens | quercetin | |
| 0.0252 | - |
pH 7.4, 37°C, enzyme UGT1A3 | Homo sapiens | kaempferol | |
| 0.0336 | - |
pH 7.4, 37°C, enzyme UGT1A1 | Homo sapiens | kaempferol | |
| 0.0379 | - |
pH 7.4, 37°C, enzyme UGT1A9 | Homo sapiens | quercetin | |
| 0.0385 | - |
pH 7.4, 37°C, enzyme UGT1A9 | Homo sapiens | kaempferol | |
| 0.109 | - |
pH 7.4, 37°C, enzyme UGT1A4 | Homo sapiens | quercetin | |
| 0.1526 | - |
pH 7.4, 37°C, enzyme UGT1A6 | Homo sapiens | quercetin | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | UGT enzymes are genetically polymorphic | Homo sapiens |
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