Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-phenyl-4H-benzo[h]chromen-4-one | - |
Homo sapiens | |
bupropion | - |
Homo sapiens | |
cyclosporine A | - |
Homo sapiens | |
dextromethorphan | - |
Homo sapiens | |
diclofenac | - |
Homo sapiens | |
ketoconazole | - |
Homo sapiens | |
midazolam | - |
Homo sapiens | |
oleandomycin | - |
Homo sapiens | |
Omeprazole | - |
Homo sapiens | |
paclitaxel | - |
Homo sapiens | |
quinidine | - |
Homo sapiens | |
testosterone | - |
Homo sapiens | |
Tolbutamide | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.013 | - |
midazolam | isoform UGT1A4, pH 7.4, 37°C | Homo sapiens | |
0.021 | - |
beta-estradiol | isoform UGT1A1, pH 7.4, 37°C | Homo sapiens | |
0.056 | - |
diclofenac | isoform UGT2B10, pH 7.4, 37°C | Homo sapiens | |
0.069 | - |
diclofenac | isoform UGT2B7, pH 7.4, 37°C | Homo sapiens | |
0.084 | - |
1-naphthol | isoform UGT1A6, pH 7.4, 37°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-naphthol + UDP-alpha-D-glucuronate | - |
Homo sapiens | 1-naphthyl-O-glucuronide + UDP | - |
? | |
beta-estradiol + UDP-alpha-D-glucuronate | - |
Homo sapiens | beta-estradiol-3-glucuronide + UDP | - |
? | |
diclofenac + UDP-alpha-D-glucuronate | - |
Homo sapiens | diclofenac D-glucuronide + UDP | - |
? | |
midazolam + UDP-alpha-D-glucuronate | - |
Homo sapiens | midazolam D-glucuronide + UDP | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0041 | - |
isoform UGT1A1, substrate beta-estradiol, pH 7.4, 37°C | Homo sapiens | ketoconazole | |
0.0049 | - |
isoform UGT1A4, substrate midazolam, pH 7.4, 37°C | Homo sapiens | paclitaxel | |
0.019 | - |
isoform UGT1A6, substrate 1-naphthol, pH 7.4, 37°C | Homo sapiens | ketoconazole | |
0.02 | - |
isoform UGT1A1, substrate beta-estradiol, pH 7.4, 37°C | Homo sapiens | paclitaxel | |
0.022 | - |
isoform UGT2B10, substrate diclofenacl, pH 7.4, 37°C | Homo sapiens | ketoconazole | |
0.023 | - |
isoform UGT1A4, substrate midazolam, pH 7.4, 37°C | Homo sapiens | cyclosporine A | |
0.023 | - |
isoform UGT1A4, substrate midazolam, pH 7.4, 37°C | Homo sapiens | 2-phenyl-4H-benzo[h]chromen-4-one | |
0.023 | - |
isoform UGT1A6, substrate 1-naphthol, pH 7.4, 37°C | Homo sapiens | midazolam | |
0.026 | - |
isoform UGT1A1, substrate beta-estradiol, pH 7.4, 37°C | Homo sapiens | midazolam | |
0.038 | - |
isoform UGT1A1, substrate beta-estradiol, pH 7.4, 37°C | Homo sapiens | 2-phenyl-4H-benzo[h]chromen-4-one | |
0.043 | - |
isoform UGT1A1, substrate beta-estradiol, pH 7.4, 37°C | Homo sapiens | testosterone | |
0.044 | - |
isoform UGT1A1, substrate beta-estradiol, pH 7.4, 37°C | Homo sapiens | oleandomycin | |
0.046 | - |
isoform UGT1A4, substrate midazolam, pH 7.4, 37°C | Homo sapiens | diclofenac | |
0.048 | - |
isoform UGT1A1, substrate beta-estradiol, pH 7.4, 37°C | Homo sapiens | cyclosporine A | |
0.056 | - |
isoform UGT1A1, substrate beta-estradiol, pH 7.4, 37°C | Homo sapiens | Omeprazole | |
0.058 | - |
isoform UGT1A4, substrate midazolam, pH 7.4, 37°C | Homo sapiens | ketoconazole | |
0.059 | - |
isoform UGT1A4, substrate midazolam, pH 7.4, 37°C | Homo sapiens | oleandomycin | |
0.06 | - |
isoform UGT2B7, substrate diclofenac, pH 7.4, 37°C | Homo sapiens | ketoconazole | |
0.062 | - |
isoform UGT2B10, substrate diclofenac, pH 7.4, 37°C | Homo sapiens | dextromethorphan | |
0.067 | - |
isoform UGT1A6, substrate 1-naphthol, pH 7.4, 37°C | Homo sapiens | 2-phenyl-4H-benzo[h]chromen-4-one | |
0.074 | - |
isoform UGT1A6, substrate 1-naphthol, pH 7.4, 37°C | Homo sapiens | paclitaxel | |
0.088 | - |
isoform UGT2B10, substrate diclofenacl, pH 7.4, 37°C | Homo sapiens | bupropion | |
0.089 | - |
isoform UGT1A4, substrate midazolam, pH 7.4, 37°C | Homo sapiens | dextromethorphan | |
0.106 | - |
isoform UGT2B10, substrate diclofenacl, pH 7.4, 37°C | Homo sapiens | midazolam | |
0.147 | - |
isoform UGT2B7, substrate diclofenac, pH 7.4, 37°C | Homo sapiens | midazolam | |
0.149 | - |
isoform UGT2B7, substrate diclofenac, pH 7.4, 37°C | Homo sapiens | 2-phenyl-4H-benzo[h]chromen-4-one | |
0.152 | - |
isoform UGT1A4, substrate midazolam, pH 7.4, 37°C | Homo sapiens | bupropion | |
0.155 | - |
isoform UGT1A1, substrate beta-estradiol, pH 7.4, 37°C | Homo sapiens | diclofenac | |
0.165 | - |
isoform UGT2B7, substrate diclofenac, pH 7.4, 37°C | Homo sapiens | testosterone | |
0.166 | - |
isoform UGT1A4, substrate midazolam, pH 7.4, 37°C | Homo sapiens | quinidine | |
0.185 | - |
isoform UGT1A6, substrate 1-naphthol, pH 7.4, 37°C | Homo sapiens | Omeprazole | |
0.192 | - |
isoform UGT1A4, substrate midazolam, pH 7.4, 37°C | Homo sapiens | diclofenac | |
0.272 | - |
isoform UGT1A1, substrate beta-estradiol, pH 7.4, 37°C | Homo sapiens | oleandomycin | |
0.281 | - |
isoform UGT1A6, substrate 1-naphthol, pH 7.4, 37°C | Homo sapiens | Tolbutamide |