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Literature summary for 2.4.1.17 extracted from

  • Ma, L.; Sun, J.; Peng, Y.; Zhang, R.; Shao, F.; Hu, X.; Zhu, J.; Wang, X.; Cheng, X.; Zhu, Y.; Wan, P.; Feng, D.; Wu, H.; Wang, G.
    Glucuronidation of edaravone by human liver and kidney microsomes: biphasic kinetics and identification of UGT1A9 as the major UDP-glucuronosyltransferase isoform (2012), Drug Metab. Dispos., 40, 734-741.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
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Homo sapiens
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
kidney
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Homo sapiens
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liver
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
edaravone + UDP-alpha-D-glucuronate i.e. 3-methyl-1-phenyl-2-pyrazolin-5-one. Edaravone glucuronidation in liver microsomes and kidney microsomes exhibits biphasic kinetics. UDP glucuronosyltransferases UGT1A1, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A10, UGT2B7, and UGT2B17 produce a significant amount of glucuronide metabolite. Among them, UGT1A9 exhibits the highest activity, followed by UGT2B17 and UGT1A7 Homo sapiens edaravone beta-D-glucuronate + UDP
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