Protein Variants | Comment | Organism |
---|---|---|
F90A | mutation in isoform 1A10, decrease in dopamine glucuronidation, no decrease in substrate affinity | Homo sapiens |
F90L | mutation in isoform 1A10, decrease in dopamine glucuronidation, no decrease in substrate affinity | Homo sapiens |
F93A | mutation in isoform 1A10, decrease in dopamine glucuronidation, no decrease in substrate affinity | Homo sapiens |
F93L | mutation in isoform 1A10, decrease in dopamine glucuronidation, no decrease in substrate affinity. Mutant conjugates dopamine at the 4-hydroxyl postion 4 times more efficiently than at the 3-OH position | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.89 | - |
dopamine | formation of dopamine-4-O-glucuronide, mutant F90A | Homo sapiens | |
1.95 | - |
dopamine | formation of dopamine-4-O-glucuronide, wild-type | Homo sapiens | |
1.99 | - |
dopamine | formation of dopamine-3-O-glucuronide, mutant F90A | Homo sapiens | |
2.19 | - |
dopamine | formation of dopamine-3-O-glucuronide, wild-type | Homo sapiens | |
2.31 | - |
dopamine | formation of dopamine-3-O-glucuronide, mutant F90L | Homo sapiens | |
2.59 | - |
dopamine | formation of dopamine-4-O-glucuronide, mutant F90L | Homo sapiens | |
2.63 | - |
dopamine | formation of dopamine-4-O-glucuronide, mutant F93A | Homo sapiens | |
2.67 | - |
dopamine | formation of dopamine-3-O-glucuronide, mutant F93L | Homo sapiens | |
2.91 | - |
dopamine | formation of dopamine-3-O-glucuronide, mutant F93A | Homo sapiens | |
3.11 | - |
dopamine | formation of dopamine-4-O-glucuronide, mutant F93L | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isoform UGT1A10 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipose tissue | main expression in small intestine, colon, and adipose tissue | Homo sapiens | - |
colon | main expression in small intestine, colon, and adipose tissue | Homo sapiens | - |
liver | low expression, activity in intestinal microsomes is markedly higher than in liver microsomes | Homo sapiens | - |
additional information | no expression in brain | Homo sapiens | - |
small intestine | main expression in small intestine, colon, and adipose tissue. Activity in intestinal microsomes is markedly higher than in liver microsomes | Homo sapiens | - |
stomach | low expression | Homo sapiens | - |
testis | low expression | Homo sapiens | - |
trachea | low expression | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-alpha-D-glucuronate + dopamine | substrate for isoform UGT1A10, no substrate for all other UGT enzymes tested | Homo sapiens | UDP + dopamine 3-O-beta-D-glucopyranosiduronic acid | - |
? | |
UDP-alpha-D-glucuronate + dopamine | - |
Homo sapiens | UDP + dopamine 4-O-beta-D-glucopyranosiduronic acid | substrate for isoform UGT1A10, no substrate for all other UGT enzymes tested | ? |