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Literature summary for 2.4.1.17 extracted from

  • Kerdpin, O.; Mackenzie, P.I.; Bowalgaha, K.; Finel, M.; Miners, J.O.
    Influence of N-terminal domain histidine and proline residues on the substrate selectivities of human UDP-glucuronosyltransferase 1A1, 1A6, 1A9, 2B7, and 2B10 (2009), Drug Metab. Dispos., 37, 1948-1955.
    View publication on PubMed
Search for more literature for 2.4.1.17

Cloned(Commentary)

Cloned (Comment) Organism
expression in HEK-293 cell Homo sapiens

Protein Variants

Protein Variants Comment Organism
H37P isoform UGT1A9, mutant lacks the ability to metabolize 4-methylumbeliferone, 1-naphthol, and naproxen Homo sapiens
H38P isoform UGT1A6, mutant lacks the ability to metabolize 4-methylumbeliferone, 1-naphthol, and naproxen Homo sapiens
H39P isoform UGT1A1, mutant lacks the ability to metabolize 4-methylumbeliferone, 1-naphthol, and naproxen Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.044
-
 Trifluoperazine isoform UGT1A4 Homo sapiens
0.305
-
 Trifluoperazine isoform UGT1A1 mutant H39P Homo sapiens
0.774
-
 lamotrigine isoform UGT1A1 mutant H39P Homo sapiens
1.579
-
 lamotrigine isoform UGT1A4 Homo sapiens
3.812
-
 lamotrigine isoform UGT1A9 mutant H37P Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-naproxen + UDP-alpha-D-glucuronate
-
 Homo sapiens UDP + beta-D-glucuronosyl (S)-naproxen
-
 ?
1-naphthol + UDP-glucuronate
-
 Homo sapiens UDP + naphth-1-yl-beta-D-glucuronide
-
 ?
4-methylumbeliferone + UDP-glucuronate
-
 Homo sapiens 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
 ?
lamotrigine + UDP-glucuronate
-
 Homo sapiens UDP + ?
-
 ?
trifluoperazine + UDP-glucuronate substrate for isoform UGT1A4 and isoform UGT1A1 mutant H39P Homo sapiens UDP + ?
-
 ?

Synonyms

Synonyms Comment Organism
UGT1A4
-
 Homo sapiens