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Literature summary for 2.4.1.17 extracted from
- Kinetic modeling of the interactions between 4-methylumbelliferone, 1-naphthol, and zidovudine glucuronidation by UDP-glucuronosyltransferase 2B7 (UGT2B7) provides evidence for multiple substrate binding and effector sites (2008), Mol. Pharmacol., 74, 1152-1162.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| stable expression of isozyme UGT2B7 Tyr268 variant in HEK-293 cells | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetic modeling of the interactions between 4-methylumbelliferone, 1-naphthol, and zidovudine glucuronidation by UGT2B7 provides evidence for multiple substrate binding and effector sites, multisite kinetic equilibria models and two-site inhibition model for a substrate exhibiting Michaelis-Menten kinetics, three-site model for heteroactivation, overview | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P16662 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | kinetic modeling of the interactions between 4-methylumbelliferone, 1-naphthol, and zidovudine glucuronidation by UGT2B7 provides evidence for multiple substrate binding and effector sites, overview | Homo sapiens | ? | - |
? | |
| UDP-D-glucuronate + 1-naphthol | - |
Homo sapiens | UDP + 1-naphthyl beta-D-glucuronoside | - |
? | |
| UDP-D-glucuronate + 4-methylumbelliferone | - |
Homo sapiens | UDP + 4-methylumbelliferonyl beta-D-glucuronoside | - |
? | |
| UDP-D-glucuronate + zidovudine | - |
Homo sapiens | UDP + zidovudine beta-D-glucuronoside | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| UDP-glucuronosyltransferase 2B7 | - |
Homo sapiens |
| UGT2B7 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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